APPLICATIONS OF NEXT-GENERATION SEQUENCING Reconstructing ancient genomes and epigenomes

被引：136

作者：

Orlando, Ludovic ^{[1
,2
]}

Gilbert, M. Thomas P. ^{[1
,3
]}

Willerslev, Eske ^{[1
]}

机构：

[1] Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen C, Denmark

[2] Univ Toulouse, Univ Paul Sabatier, Lab AMIS, CNRS UMR 5288, F-31000 Toulouse, France

[3] Curtin Univ, Dept Environm & Agr, Trace & Environm DNA Lab, Perth, WA 6102, Australia

来源：

NATURE REVIEWS GENETICS | 2015年 / 16卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

DNA-SEQUENCES; NEANDERTHAL GENOME; MISCODING LESIONS; YERSINIA-PESTIS; READ ALIGNMENT; EVOLUTION; PATTERNS; ANCESTRY; INSIGHTS; HISTORY;

D O I：

10.1038/nrg3935

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Research involving ancient DNA (aDNA) has experienced a true technological revolution in recent years through advances in the recovery of aDNA and, particularly, through applications of high-throughput sequencing. Formerly restricted to the analysis of only limited amounts of genetic information, aDNA studies have now progressed to whole-genome sequencing for an increasing number of ancient individuals and extinct species, as well as to epigenomic characterization. Such advances have enabled the sequencing of specimens of up to 1 million years old, which, owing to their extensive DNA damage and contamination, were previously not amenable to genetic analyses. In this Review, we discuss these varied technical challenges and solutions for sequencing ancient genomes and epigenomes.

引用

页码：395 / 408

页数：14

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