Flexible porous metal-organic frameworks for a controlled drug delivery

被引：1599

作者：

Horcajada, Patricia ^{[1
,4
]}

Serre, Christian ^{[4
]}

Maurin, Guillaume ^{[2
]}

Ramsahye, Naseem A. ^{[2
]}

Balas, Francisco ^{[1
]}

Vallet-Regi, Maria ^{[1
]}

Sebban, Muriel

Taulelle, Francis ^{[4
]}

Ferey, Gerard ^{[3
,4
]}

机构：

[1] Univ Complutense Madrid, Dept Quim Inorgan & Bioinorgan, Fac Farm, E-28040 Madrid, Spain

[2] Univ Montpellier 2, Inst Charles Gerhardt, CNRS, UMR 5253,UM2,ENSCM, F-34095 Montpellier 5, France

[3] Inst Univ France, Paris, France

[4] Univ Versailles St Quentin Yvelines, CNRS, UMR 8180, Inst Lavoisier, F-78035 Versailles, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 21期

关键词：

D O I：

10.1021/ja710973k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of lbuprofen (or alpha-p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt% of lbuprofen (lbuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with lbuprofen. In each case, the very slow and complete delivery of lbuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.

引用

页码：6774 / 6780

页数：7

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