Pharmacokinetics of maslinic and oleanolic acids from olive oil - Effects on endothelial function in healthy adults. A randomized, controlled, dose-response study

被引：37

作者：

de la Torre, Rafael ^{[1
,2
,3
]}

Carbo, Marceli ^{[2
]}

Pujadas, Mitona ^{[1
,3
]}

Biel, Sarah ^{[4
]}

Mesa, Maria-Dolores ^{[5
,6
]}

Covas, Maria-Isabel ^{[3
,7
]}

Exposito, Manuela ^{[4
]}

Espejo, Juan-Antonio ^{[8
]}

Sanchez-Rodriguez, Estefania ^{[5
]}

Diaz-Pellicer, Patricia ^{[1
]}

Jimenez-Valladares, Francisco ^{[9
]}

Rosa, Carmen ^{[4
]}

Pozo, Oscar ^{[1
]}

Fito, Montserrat ^{[3
,10
]}

机构：

[1] IMIM Hosp del Mar Res Inst, Integrat Pharmacol & Syst Neurosci Res Grp, Dr Aiguader 88, Barcelona 08003, Spain

[2] Univ PompeuFabra CEXS UPF, Dr Aiguader 88, Barcelona 08003, Spain

[3] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Santiago De Compostela 15706, Spain

[4] Fdn Publ Andaluza Invest Biosanitaria Andalucia O, Granada, Spain

[5] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Hlth Sci Technol Pk,Ave Conocimiento S-N, Granada 18100, Spain

[6] Complejo Hosp Univ Granada, Inst Invest Biosanitariaibs GRANADA, Granada 18014, Spain

[7] NUPROAS Nutr Project Assessment, Handesbolag NUPROAS HB, Nacka, Sweden

[8] Inst Calidad & Seguridad Alimentaria ICSA, Granada, Spain

[9] Cooperat San Francisco Asis, Granada, Spain

[10] IMIM Hosp del Mar Res Inst, Cardiovasc Risk & Nutr Res Grp, Dr Aiguader 88, Barcelona 08003, Spain

来源：

FOOD CHEMISTRY | 2020年 / 322卷

关键词：

Maslinic; Oleanolic; Bioavailability; Triterpenes; Endothelial function; Pharmacokinetics; PHYSICAL-ACTIVITY QUESTIONNAIRE; NITRIC-OXIDE; TRITERPENES; HYPERTENSION; VALIDATION;

D O I：

10.1016/j.foodchem.2020.126676

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

To date, pharmacokinetics of maslinic (MA) and oleanolic (OA) acids, at normal dietary intakes in humans, have not been evaluated, and data concerning their bioactive effects are scarce. We assessed MA and OA pharmacokinetics after ingestion of olive oils (OOs) with high and low triterpenic acid contents, and specifically the effect of triterpenes on endothelial function. We performed a double-blind, dose-response, randomized, crossover nutritional intervention in healthy adults, and observed that MA and OA increased in biological fluids in a dose-dependent manner. MA bioavailability was greater than that of OA, and consumption of pentacyclic triterpenes was associated with improved endothelial function. To the best of our knowledge, this is the first time MA pharmacokinetics, and effects on endothelial function in vivo, have been reported in humans.

引用

页数：8

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