Provitamin A Carotenoids in Grain Reduce Aflatoxin Contamination of Maize While Combating Vitamin A Deficiency

被引:35
作者
Suwarno, Willy B. [1 ,4 ]
Hannok, Pattama [1 ,2 ,5 ]
Palacios-Rojas, Natalia [1 ]
Windham, Gary [3 ]
Crossa, Jose [1 ]
Pixley, Kevin V. [1 ,2 ]
机构
[1] Int Maize & Wheat Improvement Ctr, Texcoco, Mexico
[2] Univ Wisconsin, Dept Agron, 1575 Linden Dr, Madison, WI 53706 USA
[3] ARS, Com Host Plant Resistance Res Unit, USDA, Starkville, MS USA
[4] Bogor Agr Univ, Dept Agron & Hort, Fac Agr, Bogor, Indonesia
[5] Maejo Univ, Program Agron, Chiangmai, Thailand
来源
FRONTIERS IN PLANT SCIENCE | 2019年 / 10卷
关键词
aflatoxin; beta-carotene; beta-cryptoxanthin; biofortification; maize breeding; mycotoxins; vitamin A deficiency; ASPERGILLUS EAR ROT; LYCOPENE-EPSILON-CYCLASE; OXIDATIVE STRESS; GENETIC-VARIATION; KERNEL INFECTION; RESISTANCE; CORN; ACCUMULATION; METABOLISM; LIVER;
D O I
10.3389/fpls.2019.00030
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Aflatoxin contamination of maize grain and products causes serious health problems for consumers worldwide, and especially in low-and middle-income countries where monitoring and safety standards are inconsistently implemented. Vitamin A deficiency (VAD) also compromises the health of millions of maize consumers in several regions of the world including large parts of sub-Saharan Africa. We investigated whether provitamin A (proVA) enriched maize can simultaneously contribute to alleviate both of these health concerns. We studied aflatoxin accumulation in grain of 120 maize hybrids formed by crossing 3 Aspergillus flavus resistant and three susceptible lines with 20 orange maize lines with low to high carotenoids concentrations. The hybrids were grown in replicated, artificially-inoculated field trials at five environments. Grain of hybrids with larger concentrations of beta-carotene (BC), beta-cryptoxanthin (BCX) and total proVA had significantly less aflatoxin contamination than hybrids with lower carotenoids concentrations. Aflatoxin contamination had negative genetic correlation with BCX (0.28, p < 0.01), BC (0.18, p < 0.05), and proVA (0.23, p < 0.05). The relative ease of breeding for increased proVA carotenoid concentrations as compared to breeding for aflatoxin resistance in maize suggests using the former as a component of strategies to combat aflatoxin contamination problems for maize. Our findings indicate that proVA enriched maize can be particularly beneficial where the health burdens of exposure to aflatoxin and prevalence of VAD converge with high rates of maize consumption.
引用
收藏
页数:12
相关论文
共 59 条
[1]   The antioxidant effects of vitamin A, C, and E on aflatoxin B1-induced oxidative stress in human lymphocytes [J].
Alpsoy, L. ;
Yildirim, A. ;
Agar, G. .
TOXICOLOGY AND INDUSTRIAL HEALTH, 2009, 25 (02) :121-127
[2]  
Andersson MS, 2017, AFR J FOOD AGR NUTR, V17, P11905
[3]   Heritability of aflatoxin resistance traits and correlation with drought tolerance traits in peanut [J].
Arunyanark, A. ;
Jogloy, S. ;
Wongkaew, S. ;
Akkasaeng, C. ;
Vorasoot, N. ;
Kesmala, T. ;
Patanothai, A. .
FIELD CROPS RESEARCH, 2010, 117 (2-3) :258-264
[4]   Antioxidant Secondary Metabolites in Cereals: Potential Involvement in Resistance to Fusarium and Mycotoxin Accumulation [J].
Atanasova-Penichon, Vessela ;
Barreau, Christian ;
Richard-Forget, Florence .
FRONTIERS IN MICROBIOLOGY, 2016, 7
[5]   Validation of the effects of molecular marker polymorphisms in LcyE and CrtRB1 on provitamin A concentrations for 26 tropical maize populations [J].
Babu, Raman ;
Rojas, Natalia Palacios ;
Gao, Shibin ;
Yan, Jianbing ;
Pixley, Kevin .
THEORETICAL AND APPLIED GENETICS, 2013, 126 (02) :389-399
[6]   Aflatoxin accumulation of white and yellow maize inbreds in diallel crosses [J].
Betrán, FJ ;
Isakeit, T ;
Odvody, G .
CROP SCIENCE, 2002, 42 (06) :1894-1901
[7]   Biotechnological advances for combating Aspergillus flavus and aflatoxin contamination in crops [J].
Bhatnagar-Mathur, Pooja ;
Sunkara, Sowmini ;
Bhatnagar-Panwar, Madhurima ;
Waliyar, Farid ;
Sharma, Kiran Kumar .
PLANT SCIENCE, 2015, 234 :119-132
[8]   Ferulic acid, an efficient inhibitor of type B trichothecene biosynthesis and Tri gene expression in Fusarium liquid cultures [J].
Boutigny, Anne-Laure ;
Barreau, Christian ;
Atanasova-Penichon, Vessela ;
Verdal-Bonnin, Marie-Noelle ;
Pinson-Gadais, Laetitia ;
Richard-Forget, Florence .
MYCOLOGICAL RESEARCH, 2009, 113 :746-753
[9]   Inheritance of resistance to aflatoxin production and Aspergillus ear rot of corn from the cross of inbreds B73 and Oh516 [J].
Busboom, KN ;
White, DG .
PHYTOPATHOLOGY, 2004, 94 (10) :1107-1115
[10]   SAMPLING, SAMPLE PREPARATION, AND SAMPLING PLANS FOR FOODSTUFFS FOR MYCOTOXIN ANALYSIS [J].
CAMPBELL, AD ;
WHITAKER, TB ;
POHLAND, AE ;
DICKENS, JW ;
PARK, DL .
PURE AND APPLIED CHEMISTRY, 1986, 58 (02) :305-314