Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

被引：204

作者：

Stremmel, C. ^{[1
,2
]}

Schuchert, R. ^{[1
,2
]}

Wagner, F. ^{[1
,2
]}

Thaler, R. ^{[1
,2
]}

Weinberger, T. ^{[1
,2
]}

Pick, R. ^{[2
]}

Mass, E. ^{[3
,4
]}

Ishikawa-Ankerhold, H. C. ^{[1
,2
]}

Margraf, A. ^{[2
]}

Hutter, S. ^{[5
]}

Vagnozzi, R. ^{[6
]}

Klapproth, S. ^{[7
]}

Frampton, J. ^{[8
]}

Yona, S. ^{[9
]}

Scheiermann, C. ^{[2
]}

Molkentin, J. D. ^{[6
,10
]}

Jeschke, U. ^{[5
]}

Moser, M. ^{[7
]}

Sperandio, M. ^{[2
]}

Massberg, S. ^{[1
,2
,11
]}

Geissmann, F. ^{[3
]}

Schulz, C. ^{[1
,2
,11
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Klinikum Univ, Med Klin & Poliklin 1, Marchioninistr 15, D-81377 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Walter Brendel Ctr Expt Med, Marchioninistr 15, D-81377 Munich, Germany

[3] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Program Immunol, 1275 York Ave, New York, NY 10065 USA

[4] Univ Bonn, Dev Biol Innate Immune Syst, LIMES Inst, Carl Troll Str 31, D-53115 Bonn, Germany

[5] Ludwig Maximilians Univ Munchen, Klin & Poliklin Frauenheilkunde & Geburtshilfe, Klinikum Univ, Maistr 11, D-80337 Munich, Germany

[6] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[7] Max Planck Inst Biochem, Dept Mol Med, Klopferspitz 18, D-82152 Martinsried, Germany

[8] Univ Birmingham, Inst Canc & Genom Sci, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England

[9] Weizmann Inst Sci, Dept Immunol, 234 Herzl St, IL-76100 Rehovot, Israel

[10] Cincinnati Childrens Hosp Med Ctr, Howard Hughes Med Inst, 3333 Burnet Ave, Cincinnati, OH 45229 USA

[11] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Biedersteiner Str 29, D-80802 Munich, Germany

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

HEMATOPOIETIC STEM-CELLS; MONONUCLEAR PHAGOCYTE SYSTEM; AORTIC ENDOTHELIUM; MYELOID CELLS; IN-VIVO; MOUSE; MONOCYTES; ORIGIN; MICROGLIA; EMERGE;

D O I：

10.1038/s41467-017-02492-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX(3)CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.

引用

页数：14

共 70 条

[1] Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities [J].

Bain, Calum C. ;

Hawley, Catherine A. ;

Garner, Hannah ;

Scott, Charlotte L. ;

Schridde, Anika ;

Steers, Nicholas J. ;

Mack, Matthias ;

Joshi, Anagha ;

Guilliams, Martin ;

Mowat, Allan Mc I. ;

Geissmann, Frederic ;

Jenkins, Stephen J. .

NATURE COMMUNICATIONS, 2016, 7

[2] Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice [J].

Bain, Calum C. ;

Bravo-Blas, Alberto ;

Scott, Charlotte L. ;

Perdiguero, Elisa Gomez ;

Geissmann, Frederic ;

Henri, Sandrine ;

Malissen, Bernard ;

Osborne, Lisa C. ;

Artis, David ;

Mowat, Allan Mci .

NATURE IMMUNOLOGY, 2014, 15 (10) :929-U236

[3] Haematopoietic stem cells derive directly from aortic endothelium during development [J].

Bertrand, Julien Y. ;

Chi, Neil C. ;

Santoso, Buyung ;

Teng, Shutian ;

Stainier, Didier Y. R. ;

Traver, David .

NATURE, 2010, 464 (7285) :108-U120

[4] Three pathways to mature macrophages in the early mouse yolk sac [J].

Bertrand, JY ;

Jalil, A ;

Klaine, M ;

Jung, S ;

Cumano, A ;

Godin, I .

BLOOD, 2005, 106 (09) :3004-3011

[5] Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells [J].

Boiers, Charlotta ;

Carrelha, Joana ;

Lutteropp, Michael ;

Luc, Sidinh ;

Green, Joanna C. A. ;

Azzoni, Emanuele ;

Woll, Petter S. ;

Mead, Adam J. ;

Hultquist, Anne ;

Swiers, Gemma ;

Perdiguero, Elisa Gomez ;

Macaulay, Iain C. ;

Melchiori, Luca ;

Luis, Tiago C. ;

Kharazi, Shabnam ;

Bouriez-Jones, Tiphaine ;

Deng, Qiaolin ;

Ponten, Annica ;

Atkinson, Deborah ;

Jensen, Christina T. ;

Sitnicka, Ewa ;

Geissmann, Frederic ;

Godin, Isabelle ;

Sandberg, Rickard ;

de Bruijn, Marella F. T. R. ;

Jacobsen, Sten Eirik W. .

CELL STEM CELL, 2013, 13 (05) :535-548

[6] In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium [J].

Boisset, Jean-Charles ;

van Cappellen, Wiggert ;

Andrieu-Soler, Charlotte ;

Galjart, Niels ;

Dzierzak, Elaine ;

Robin, Catherine .

NATURE, 2010, 464 (7285) :116-U131

[7] Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal [J].

Carlin, Leo M. ;

Stamatiades, Efstathios G. ;

Auffray, Cedric ;

Hanna, Richard N. ;

Glover, Leanne ;

Vizcay-Barrena, Gema ;

Hedrick, Catherine C. ;

Cook, H. Terence ;

Diebold, Sandra ;

Geissmann, Frederic .

CELL, 2013, 153 (02) :362-375

[8] The origin and cell lineage of microglia - New concepts [J].

Chan, W. Y. ;

Kohsaka, S. ;

Rezaie, P. .

BRAIN RESEARCH REVIEWS, 2007, 53 (02) :344-354

[9] CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells [J].

Chang, Gin-Wen ;

Davies, John Q. ;

Stacey, Martin ;

Yona, Simon ;

Bowdish, Dawn M. E. ;

Hamann, Jorg ;

Chen, Tse-Ching ;

Lin, Chun-Yen ;

Gordon, Siamon ;

Lin, Hsi-Hsien .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 353 (01) :133-138

[10]

Cho CH, 2000, MOL CELLS, V10, P712

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