Robust Buchwald-Hartwig amination enabled by ball-milling

被引：63

作者：

Cao, Qun ^{[1
]}

Nicholson, William I. ^{[1
]}

Jones, Andrew C. ^{[1
]}

Browne, Duncan L. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3EQ, S Glam, Wales

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

N-HETEROCYCLIC CARBENES; ARYL CHLORIDES; MECHANOCHEMISTRY; COMPLEXES; PRECATALYST; CATALYSTS; LIGANDS; NHC;

D O I：

10.1039/c8ob01781f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An operationally simple mechanochemical method for the Pd catalysed Buchwald-Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.

引用

页码：1722 / 1726

页数：5

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