SagS and its unorthodox contributions to Pseudomonas aeruginosa biofilm development

被引：12

作者：

Park, Soyoung ^{[1
,2
]}

Sauer, Karin ^{[1
,2
]}

机构：

[1] SUNY Binghamton, Dept Biol Sci, Binghamton, NY USA

[2] SUNY Binghamton, Binghamton Biofilm Res Ctr, Binghamton, NY USA

来源：

BIOFILM | 2021年 / 3卷

基金：

美国国家卫生研究院;

关键词：

CYCLIC-DI-GMP; SWARMING MOTILITY; DIGUANYLATE CYCLASE; RESPONSE REGULATOR; SIGNALING PATHWAYS; BACTERIAL BIOFILMS; RESISTANCE; TOLERANCE; PHOSPHODIESTERASE; SYSTEM;

D O I：

10.1016/j.bioflm.2021.100059

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Pseudomonas aeruginosa orphan sensor SagS (PA2824) was initially reported as one of three orphan sensor kinases capable of activating HptB, a component of the HptB signaling pathway that intersects with the Gac/Rsm signaling pathway and fine-tunes P. aeruginosa motility and pathogenesis. Since then, this orphan sensor has been reported to be involved in other, unorthodox signaling pathways serving additional functions. The present review is aimed at summarizing the various functions of SagS, with an emphasis on its toggle or dual switch functions, and highlighting the role of SagS as a hub at which the various signaling pathways intersect, to regulate the transition from the planktonic to the sessile mode of growth, as well as the transition of surface-associated cells to a drug tolerant state.

引用

页数：8

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