Have we found the tip link, transduction channel, and gating spring of the hair cell?

被引：43
作者：
Gillespie, PG
Dumont, RA
Kachar, B
机构：
[1] Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA
[3] Natl Inst Deafness & Other Commun Disorders, Sect Struct Cell Biol, NIH, Bethesda, MD 20892 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 04期
关键词：
D O I：
10.1016/j.conb.2005.06.007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent reports have offered candidates for key components of the apparatus used for mechanotransduction in hair cells. TRPA1 and cadherin 23 have been proposed to be the transduction channel and component of the tip link, respectively; moreover, ankyrin repeats in TRPA1 have been proposed to be the gating spring. Although these are excellent candidates for the three components, definitive experiments supporting each identification have yet to be per-formed.
引用
收藏
页码：389 / 396
页数：8
相关论文
共 44 条
[1]   TIP-LINK INTEGRITY AND MECHANICAL TRANSDUCTION IN VERTEBRATE HAIR-CELLS [J].
ASSAD, JA ;
SHEPHERD, GMG ;
COREY, DP .
NEURON, 1991, 7 (06) :985-994
[2]  
ASSAD JA, 1992, J NEUROSCI, V12, P3291
[3]   Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle [J].
Boëda, B ;
El-Amraoui, A ;
Bahloul, A ;
Goodyear, R ;
Daviet, L ;
Blanchard, S ;
Perfettini, I ;
Fath, KR ;
Shorte, S ;
Reiners, J ;
Houdusse, A ;
Legrain, P ;
Wolfrum, U ;
Richardson, G ;
Petit, C .
EMBO JOURNAL, 2002, 21 (24) :6689-6699
[4]   Hearing in Drosophila:: Development of Johnston's organ and emerging parallels to vertebrate ear development [J].
Boekhoff-Falk, G .
DEVELOPMENTAL DYNAMICS, 2005, 232 (03) :550-558
[5]   C-cadherin ectodomain structure and implications for cell adhesion mechanisms [J].
Boggon, TJ ;
Murray, J ;
Chappuis-Flament, S ;
Wong, E ;
Gumbiner, BM ;
Shapiro, L .
SCIENCE, 2002, 296 (5571) :1308-1313
[6]   Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D [J].
Bolz, H ;
von Brederlow, B ;
Ramírez, A ;
Bryda, EC ;
Kutsche, K ;
Nothwang, HG ;
Seeliger, M ;
Cabrera, MDS ;
Vila, MC ;
Molina, OP ;
Gal, A ;
Kubisch, C .
NATURE GENETICS, 2001, 27 (01) :108-112
[7]   Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23 [J].
Bork, JM ;
Peters, LM ;
Riazuddin, S ;
Bernstein, SL ;
Ahmed, ZM ;
Ness, SL ;
Polomeno, R ;
Ramesh, A ;
Schloss, M ;
Srisailpathy, CRS ;
Wayne, S ;
Bellman, S ;
Desmukh, D ;
Ahmed, Z ;
Khan, SN ;
Kaloustian, VMD ;
Li, XC ;
Lalwani, A ;
Riazuddin, S ;
Bitner-Glindzicz, M ;
Nance, WE ;
Liu, XZ ;
Wistow, G ;
Smith, RJH ;
Griffith, AJ ;
Wilcox, ER ;
Friedman, TB ;
Morell, RJ .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (01) :26-37
[8]   TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells [J].
Corey D.P. ;
Garcia-Añoveros J. ;
Holt J.R. ;
Kwan K.Y. ;
Lin S.-Y. ;
Vollrath M.A. ;
Amalfitano A. ;
Cheung E.L.-M. ;
Derfler B.H. ;
Duggan A. ;
Géléoc G.S.G. ;
Gray P.A. ;
Hoffman M.P. ;
Rehm H.L. ;
Tamasauskas D. ;
Zhang D.-S. .
Nature, 2004, 432 (7018) :723-730
[9]   Hearing - Tightrope act [J].
Corey, DP ;
Sotomayor, M .
NATURE, 2004, 428 (6986) :901-903
[10]   Calcium imaging of single stereocilia in hair cells: Localization of transduction channels at both ends of tip links [J].
Denk, W ;
Holt, JR ;
Shepherd, GMG ;
Corey, DP .
NEURON, 1995, 15 (06) :1311-1321
12345