Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium

被引：11

作者：

Tala, Michel Feussi ^{[1
]}

Talontsi, Ferdinand Mouafo ^{[2
]}

Zeng, Guang-Zhi ^{[1
]}

Wabo, Hippolyte Kamdem ^{[3
]}

Tan, Ning-Hua ^{[1
]}

Spiteller, Michael ^{[2
]}

Lane, Pierre ^{[3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] TU Dortmund, Chair Environm Chem & Analyt Chem, Fac Chem, Inst Environm Res INFU, D-44221 Dortmund, Germany

[3] Univ Dschang, Dept Chem, Dschang, Cameroon

来源：

FITOTERAPIA | 2015年 / 102卷

关键词：

Hypericum riparium; Phloroglucinols; Butenolide; Xanthones; Antimicrobial; Cytotoxicity; CHEMICAL-CONSTITUENTS; XANTHONES; ANTIBACTERIAL; DERIVATIVES; TERPENOIDS; CHEMISTRY;

D O I：

10.1016/j.fitote.2015.02.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay guided fractionation of Hypericum riparium leaves extract has resulted in the isolation and characterization of three new compounds namely chipericumin E (1), hyperenone C (3), and hyperixanthone (5), together with twenty known compounds. Their structures were elucidated based on comprehensive interpretation of spectroscopic and spectrometric data. Compounds 1-4, and 6-8 displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxic effects on the human gastric cell line BGC-823 with IC50 values ranging from 6.54 to 18.50 mu M. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：149 / 155

页数：7

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