Sesquiterpenes and Cyclopeptides from the Endophytic Fungus Trichoderma asperellum Samuels, Lieckf. & Nirenberg

被引：23

作者：

Ding, Gang ^{[1
,2
]}

Chen, Amanda Juan ^{[1
,2
]}

Lan, Jin ^{[1
,2
]}

Zhang, Hongwu ^{[1
,2
]}

Chen, Xiangdong ^{[1
,2
]}

Liu, Xingzhong ^{[3
]}

Zou, Zhongmei ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Chinese Acad Sci, Key Lab Systemat Mycol & Lichenol, Inst Microbiol, Beijing 100190, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2012年 / 9卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Trichoderma asperellum; Tichodones A?-?C; Peptides; Sesquiterpenes; Cyclopeptides; Antibacterial activity; SKELETON;

D O I：

10.1002/cbdv.201100185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trichodones AC (13, resp.), three new sesquiterpenes, together with the two known cyclopeptides PF1022F and halobacillin (4 and 5, resp.), have been isolated from the crude extract of the endophytic fungus Trichoderma asperellum Samuels, Lieckf. & Nirenberg residing in the traditional Chinese medicinal plant Panax notoginseng (Burkill) F.H.Chen. The structures and configurations of compounds 13 were determined by NMR spectroscopy and mass spectrometry. The relative configuration for 1 was determined by analysis of its pertinent coupling constants and NOESY correlations, whereas the absolute configuration of 1 was established by CD spectroscopy. Compounds 4 and 5 displayed antibacterial activities against Enterococcus faecium (CGMCC 1.2025) with IC50 values of 7.30 and 5.24 mu m, and against Staphylococcus aureus COL (CGMCC 1.2465) with IC50 values of 19.02 and 14.00 mu M, respectively.

引用

页码：1205 / 1212

页数：8

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