The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention of Experimental Asthma

被引：53

作者：

Horka, Helena ^{[2
,3
]}

Staudt, Valerie ^{[1
]}

Klein, Matthias ^{[1
]}

Taube, Christian ^{[4
]}

Reuter, Sebastian ^{[5
]}

Dehzad, Nina ^{[5
]}

Andersen, John F. ^{[6
]}

Kopecky, Jan ^{[2
,3
]}

Schild, Hansjoerg ^{[1
]}

Kotsyfakis, Michalis ^{[2
,3
]}

Hoffmann, Markus ^{[1
]}

Gerlitzki, Bastian ^{[1
]}

Stassen, Michael ^{[1
]}

Bopp, Tobias ^{[1
]}

Schmitt, Edgar ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Immunol, D-55131 Mainz, Germany

[2] Univ S Bohemia, Inst Parasitol, Ctr Biol, Acad Sci Czech Republ, Ceske Budejovice 37005, Czech Republic

[3] Univ S Bohemia, Fac Sci, Ceske Budejovice 37005, Czech Republic

[4] Leiden Univ, Dept Pulmonol, Med Ctr, NL-2333 ZA Leiden, Netherlands

[5] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Med Clin 3, D-55131 Mainz, Germany

[6] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOLOGY | 2012年 / 188卷 / 06期

关键词：

CELL-MEDIATED SUPPRESSION; CD4(+) T-CELLS; IXODES-SCAPULARIS; AIRWAY INFLAMMATION; EPITHELIAL-CELLS; TGF-BETA; INTERLEUKIN; 9; EXPRESSION; ANTIBODY; DISEASE;

D O I：

10.4049/jimmunol.1100529

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells. Thus, alternative to IL-9 neutralization sialostatin L provides the basis for the development of innovative therapeutic strategies to treat asthma. The Journal of Immunology, 2012, 188: 2669-2676.

引用

页码：2669 / 2676

页数：8

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