Novel S100A7 (psoriasin)/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function

被引：64

作者：

Wolf, Ronald ^{[1
,2
]}

Ruzicka, Thomas ^{[1
]}

Yuspa, Stuart H. ^{[2
]}

机构：

[1] Univ Munich, Dept Dermatol, D-80337 Munich, Germany

[2] NCI, Lab Canc Biol & Genet, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

AMINO ACIDS | 2011年 / 41卷 / 04期

关键词：

Calcium-binding protein; S100; Koebnerisin; Psoriasin; Evolution; Paralogs; RAGE; Innate immunity; Inflammation; Cancer; GLYCATION END-PRODUCTS; EPIDERMAL DIFFERENTIATION COMPLEX; HUMAN-CHROMOSOME; 1Q21; PSORIASIN S100A7; CORNIFIED ENVELOPE; ATOPIC-DERMATITIS; BREAST-CANCER; SUBCELLULAR-LOCALIZATION; MOLECULAR-CLONING; PROTEIN PSORIASIN;

D O I：

10.1007/s00726-010-0666-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S100A7 (psoriasin) and S100A15 (koebnerisin) were first identified in inflamed psoriatic skin. They are of major interest because of their putative functional roles in innate immunity, epidermal cell maturation, and epithelial tumorigenesis. Human S100A7 and S100A15 have lately evolved by gene duplications within the epidermal differentiation complex (chromosome 1q21) during primate evolution forming a novel S100 subfamily. Therefore, S100A7 and S100A15 are almost identical in sequence (> 90%) and are difficult to discriminate. Despite their high homology, S100A7 and S100A15 are distinct in tissue distribution, regulation, and function, and thus, exemplary for the diversity within the S100 family. Their different properties are compelling reasons to discriminate S100A7 (psoriasin) and S100A15 (koebnerisin) in epithelial homeostasis, inflammation, and cancer.

引用

页码：789 / 796

页数：8

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