Potential Therapeutic Application of Local Anesthetics in Cancer Treatment

被引：20
作者：
Jin, Zhaosheng [1 ]
Zhang, William [1 ]
Liu, Hengrui [1 ]
Ding, Arianna [1 ]
Lin, Yongjian [2 ]
Wu, Shao-Xiong [3 ]
Lin, Jun [1 ]
机构：
[1] SUNY Stony Brook, Dept Anesthesiol, Hlth Sci Ctr, Stony Brook, NY 11794 USA
[2] Cedar Sinai Med Ctr, Dept Anesthesiol, 444 S San Vicente Blvd 1101, Los Angeles, CA 90048 USA
[3] Sun Yat Sen Univ Canc Ctr, Dept Radiat Oncol, 651 Dongfeng Rd East, Guangzhou 510060, Peoples R China
来源：
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY | 2022年 / 17卷 / 04期
关键词：
Cancer; immunomodulation; ion channels; local anesthetics; opioids; pain; stress response; INTRAVENOUS LIDOCAINE INFUSION; ACTIVATED PROTEIN-KINASE; BREAST-CANCER; EPIDURAL-ANESTHESIA; POSTOPERATIVE PAIN; GASTRIC-CANCER; GROWTH-FACTOR; CYTOKINE RESPONSE; DOUBLE-BLIND; LUNG-CANCER;
D O I：
10.2174/1574892817666220119121204
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Local anesthetics are voltage-gated sodium channel blockers primarily administered locally or to the innervating nerves for anesthetic or analgesic purposes. In vitro studies have found direct effects of local anesthetics on cancer cells, such as impact on cancer cell proliferation, apoptosis, migration, invasion, and chemosensitivity, by multiple mechanisms. So far, in vivo evidence regarding the effect of local anesthetics on cancer cell lines is relatively lacking. Local and regional anesthesia administration has been reported to reduce postoperative pain and opioid use in cancer treatment. Additionally, regional anesthesia may reduce the perioperative stress response. However, the clinical therapeutic application of local anesthetics in cancer remains exploratory. In this review, we will discuss the direct and indirect effects of local anesthetics on cancer cells, and discuss the current evidence related to the use of local anesthetics in the treatment of cancer.
引用
收藏
页码：326 / 342
页数：17
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