Mechanisms of viral membrane fusion and its inhibition

被引：1104

作者：

Eckert, DM ^{[1
]}

Kim, PS ^{[1
]}

机构：

[1] MIT, Dept Biol, Whitehead Inst Biomed Res, Howard Hughes Med Inst, Cambridge, MA 02142 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2001年 / 70卷

关键词：

viral entry; influenza hemagglutinin; HIV-1; gp41; trimer-of-hairpins; spring loaded; prehairpin intermediate;

D O I：

10.1146/annurev.biochem.70.1.777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.

引用

页码：777 / 810

页数：34

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