Post-translational modifications of EMT transcriptional factors in cancer metastasis

被引:12
作者
Chang, Rui [2 ]
Zhang, Peng [1 ]
You, Jiacong [2 ]
机构
[1] Tianjin Med Univ, Gen Hosp, Dept Cardiothorac Surg, Tianjin 300052, Peoples R China
[2] Tianjin Med Univ, Gen Hosp, Tianjin Lung Canc Inst, Tianjin Key Lab Lung Canc Metastasis & Tumor Micr, Tianjin 300052, Peoples R China
关键词
EMT; acetylation; phosphorylation; transcriptional factor; EPITHELIAL-MESENCHYMAL TRANSITION; E-CADHERIN EXPRESSION; BREAST-CANCER; HISTONE DEACETYLASE; GSK-3-BETA-MEDIATED PHOSPHORYLATION; LUNG-CANCER; DNA-DAMAGE; SNAIL; PROMOTES; CELLS;
D O I
10.1515/biol-2016-0033
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Metastasis is an important reason for death of cancer patients which characterized as the formation of secondary cancers at distant sites. Epithelial-mesenchymal transition (EMT) is a dynamic process that appear to facilitate tumor metastasis in various cancers by switching epithelial cells into mesenchymal properties. Although previous investigation suggested a key role of EMT transcriptional factors in suppression of E-cadherin, the association of these factors with other cellular regulators in cancer metastasis need to be fully elucidated. Post-translational modifications (PTMs), such as acetylation and phosphorylation, have emerged as an important mechanism to modulate biological behavior of substrate proteins. In this review, we summarized protein modification and subsequent function changes of Snail, Twist and ZEB, as well as their influence on tumor progression. Acetylation of EMT transcriptional factors usually cause nuclear localization and/or protein stabilization thus contribute to E-cadherin repression. Besides, Twist and ZEB were phosphorylated by diverse kinases to promote metastasis in many cancers, while Snail was negatively regulated by phosphorylation to degradation. Then, the potential of therapy for metastasis by targeting PTMs-involved regulation of EMT transcriptional factors were discussed.
引用
收藏
页码:237 / 243
页数:7
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