Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3)

被引：14

作者：

Kuduk, Scott D. ^{[1
]}

Chang, Ronald K. ^{[1
]}

Di Marco, Christina N. ^{[1
]}

DiPardo, Robert M. ^{[1
]}

Cook, Sean P. ^{[2
]}

Cato, Matthew J. ^{[2
]}

Jovanovska, Aneta ^{[2
]}

Urban, Mark O. ^{[2
]}

Leitl, Michael ^{[2
]}

Spencer, Robert H. ^{[2
]}

Kane, Stefanie A. ^{[2
]}

Hartman, George D. ^{[1
]}

Bilodeau, Mark T. ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

[2] Merck Res Labs, Dept Pain Res, West Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 14期

关键词：

ASIC3; Pain; Non-amidine; Blood-to-plasma; A-317567; AMYGDALA; SENSORS; FEAR;

D O I：

10.1016/j.bmcl.2011.05.064

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzothiophene methyl amines were examined in an effort to identify non-amidine chemotypes with reduced polypharmacology from existing leads with the goal of finding potent ASIC3 channel blockers to advance the therapeutic evaluation of ASIC3 inhibition. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4255 / 4258

页数：4

共 47 条

[1] Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D.
Chang, Ronald K.
Wai, Jenny M. -C.
Di Marco, Christina N.
Cofre, Victoria
DiPardo, Robert M.
Cook, Sean P.
Cato, Matthew J.
Jovanovska, Aneta
Urban, Mark O.
Leitl, Michael
Spencer, Robert H.
Kane, Stefanie A.
Hartman, George D.
Bilodeau, Mark T.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (15) : 4059 - 4063
[2] Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D.
Di Marco, Christina N.
Chang, Ronald K.
DiPardo, Robert M.
Cook, Sean P.
Cato, Matthew J.
Jovanovska, Aneta
Urban, Mark O.
Leitl, Michael
Spencer, Robert H.
Kane, Stefanie A.
Bilodeau, Mark T.
Hartman, George D.
Bock, Mark G.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (09) : 2514 - 2518
[3] Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)
Osmakov, Dmitry, I
Koshelev, Sergey G.
Ivanov, Igor A.
Andreev, Yaroslav A.
Kozlov, Sergey A.
BIOMOLECULES, 2019, 9 (09)
[4] A Role for Acid-sensing Ion Channel 3, but Not Acid-sensing Ion Channel 2, in Sensing Dynamic Mechanical Stimuli
Borzan, Jasenka
Zhao, Chengshui
Meyer, Richard A.
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ANESTHESIOLOGY, 2010, 113 (03) : 647 - 654
[5] Nocistatin and Products of Its Proteolysis Are Dual Modulators of Type 3 Acid-Sensing Ion Channels (ASIC3) with Algesic and Analgesic Properties
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Tarasova, Nadezhda V.
Nedorubov, Andrey A.
Palikov, Victor A.
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Andreev, Yaroslav A.
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[6] Nocistatin and Products of Its Proteolysis Are Dual Modulators of Type 3 Acid-Sensing Ion Channels (ASIC3) with Algesic and Analgesic Properties
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Nadezhda V. Tarasova
Andrey A. Nedorubov
Victor A. Palikov
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Biochemistry (Moscow), 2023, 88 : 2137 - 2145
[7] Acid-sensing ion channel 3: An analgesic target
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CHANNELS, 2021, 15 (01) : 94 - 127
[8] Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3
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Min, M. -Y.
Lin, C. -C.
Chen, W. -N.
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[9] Role of the Acid-Sensing Ion Channel 3 in Blood Volume Control
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Chen, Chih-Cheng
CIRCULATION JOURNAL, 2011, 75 (04) : 874 - 883
[10] Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids
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EMBO JOURNAL, 2016, 35 (04) : 414 - 428

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