Vγ9Vδ2 T cell-based immunotherapy in hematological malignancies: from bench to bedside

被引：37

作者：

Castella, Barbara ^{[1
,2
,3
]}

Vitale, Candida ^{[1
,2
,3
]}

Coscia, Marta ^{[1
,2
,3
]}

Massaia, Massimo ^{[1
]}

机构：

[1] Osped San Giovanni Battista Torino, Div Univ Ematol, I-10126 Turin, Italy

[2] Osped San Giovanni Battista Torino, Lab Ematol Oncolog, Ctr Ric Med Sperimentale CeRMS, I-10126 Turin, Italy

[3] Univ Turin, Turin, Italy

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2011年 / 68卷 / 14期

关键词：

V gamma 9V delta 2 T cells; Lymphoma; MM; Immunotherapy; Zoledronic acid; Mevalonate pathway; CHRONIC LYMPHOCYTIC-LEUKEMIA; ANTI-CD20; MONOCLONAL-ANTIBODY; HLA CLASS-I; MULTIPLE-MYELOMA; TUMOR-CELLS; ZOLEDRONIC ACID; ANTITUMOR CYTOTOXICITY; BROMOHYDRIN PYROPHOSPHATE; EFFECTOR FUNCTIONS; SIDE POPULATION;

D O I：

10.1007/s00018-011-0704-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many hematological malignancies consist of tumor cells that are spontaneously recognized and killed by V gamma 9V delta 2 T cells. These tumor cells generate high amounts of intracellular phosphorylated metabolites mimicking the natural ligands and display a wide range of stress-induced self-ligands that are recognized by V gamma 9V delta 2 T cells via TCR-dependent and TCR-independent mechanisms. The intrinsic features of V gamma 9V delta 2 T cells and that of tumor cells of hematological origin constitute an ideal combination from which to develop V gamma 9V delta 2 T cell-based immune interventions. In this review, we will discuss the rationale, preclinical and clinical data in favor of this therapeutic strategy and the future perspectives of its development.

引用

页码：2419 / 2432

页数：14

共 92 条

[21] GAMMA-DELTA-T-CELL CLONES AND NATURAL-KILLER-CELL CLONES MEDIATE DISTINCT PATTERNS OF NONMAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED CYTOLYSIS [J].

FISCH, P ;

MALKOVSKY, M ;

BRAAKMAN, E ;

STURM, E ;

BOLHUIS, RLH ;

PRIEVE, A ;

SOSMAN, JA ;

LAM, VA ;

SONDEL, PM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) :1567-1579

[22] Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ/Vδ2 T cells in tumor immunity [J].

Fisch, P ;

Meuer, E ;

Pende, D ;

Rothenfusser, S ;

Viale, O ;

Kock, S ;

Ferrone, S ;

Fradelizi, D ;

Klein, G ;

Moretta, L ;

Rammensee, HG ;

Boon, T ;

Coulie, P ;

van der Bruggen, P .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) :3368-3379

[23] RECOGNITION BY HUMAN V-GAMMA-9/V-DELTA-2 T-CELLS OF A GROEL HOMOLOG ON DAUDI-BURKITT LYMPHOMA-CELLS [J].

FISCH, P ;

MALKOVSKY, M ;

KOVATS, S ;

STURM, E ;

BRAAKMAN, E ;

KLEIN, BS ;

VOSS, SD ;

MORRISSEY, LW ;

DEMARS, R ;

WELCH, WJ ;

BOLHUIS, RLH ;

SONDEL, PM .

SCIENCE, 1990, 250 (4985) :1269-1273

[24] Statin use and risk of lymphoid neoplasms:: Results from the European case-control study EPILYMPH [J].

Fortuny, Joan ;

de Sanjose, Silvia ;

Becker, Nikolaus ;

Maynadie, Marc ;

Cocco, Pier Luigi ;

Staines, Anthony ;

Foretova, Lenka ;

Vornanen, Martine ;

Brennan, Paul ;

Nieters, Alexandra ;

Alvaro, Tomas ;

Boffetta, Paolo .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (05) :921-925

[25] Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine [J].

Foster, A. E. ;

Okur, F. V. ;

Biagi, E. ;

Lu, A. ;

Dotti, G. ;

Yvon, E. ;

Savoldo, B. ;

Carrum, G. ;

Goodell, M. A. ;

Heslop, H. E. ;

Brenner, M. K. .

LEUKEMIA, 2010, 24 (03) :563-572

[26]

Gaidarova, 2009, ASH ANN M, P2616

[27] Different γ/δ T clones sustain GVM and GVH effects in multiple myeloma patients after non-myeloablative transplantation [J].

Galimberti, S ;

Benedetti, E ;

Morabito, F ;

Petrini, L ;

Battolla, B ;

Papineschi, F ;

Fazzi, R ;

Ciabatti, E ;

Martino, M ;

Cuzzola, M ;

Console, G ;

Iacopino, P ;

Petrini, M .

LEUKEMIA RESEARCH, 2006, 30 (05) :529-535

[28] Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies [J].

Gertner-Dardenne, Julie ;

Bonnafous, Cecile ;

Bezombes, Christine ;

Capietto, Aude-Helene ;

Scaglione, Virginie ;

Ingoure, Sophie ;

Cendron, Delphine ;

Gross, Emilie ;

Lepage, Jean-Francois ;

Quillet-Mary, Anne ;

Ysebaert, Loic ;

Laurent, Guy ;

Sicard, Helene ;

Fournie, Jean-Jacques .

BLOOD, 2009, 113 (20) :4875-4884

[29] An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis [J].

Giraudo, E ;

Inoue, M ;

Hanahan, D .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (05) :623-633

[30] MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells costimulates pamidronate-activated γδ lymphocytes [J].

Girlanda, S ;

Fortis, C ;

Belloni, D ;

Ferrero, E ;

Ticozzi, P ;

Sciorati, C ;

Tresoldi, M ;

Vicari, A ;

Spies, T ;

Groh, V ;

Cappio, FC ;

Ferrarini, M .

CANCER RESEARCH, 2005, 65 (16) :7502-7508

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