Transient Bacteremia Promotes Catheter-Related Central Venous Thrombosis through Neutrophil Extracellular Traps

被引：5

作者：

Chen, Jeng-Wei ^{[1
,2
]}

Hsu, Chih-Chieh ^{[3
,4
]}

Su, Chien-Chia ^{[2
,5
]}

Hsu, Ron-Bin ^{[1
]}

Chiu, Yen-Ling ^{[2
,6
,7
]}

Jung, Chiau-Jing ^{[8
]}

Chia, Jean-San ^{[2
,4
,9
]}

机构：

[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Surg,Div Cardiovasc Surg, Taipei, Taiwan

[2] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan

[3] Natl Taiwan Univ, Sch Dent, Grad Inst Oral Biol, Taipei, Taiwan

[4] Natl Taiwan Univ, Sch Dent, Grad Inst Clin Dent, Taipei, Taiwan

[5] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Ophthalmol, Taipei, Taiwan

[6] Far Eastern Mem Hosp, Dept Med, Div Nephrol, New Taipei, Taiwan

[7] Yuan Ze Univ, Coll Informat, Dept Comp Sci & Engn, Grad Program Biomed Informat, Taoyuan, Taiwan

[8] Taipei Med Univ, Coll Med, Sch Med, Dept Microbiol & Immunol, 250 Wuxing St, Taipei 11031, Taiwan

[9] Natl Taiwan Univ, Coll Med, Grad Inst Immunol, Taipei, Taiwan

来源：

THROMBOSIS AND HAEMOSTASIS | 2022年 / 122卷 / 07期

关键词：

transient bacteremia; neutrophil extracellular traps; Staphylococcus aureus; catheter-related central venous thrombosis; VEIN WALL ADJACENT; STAPHYLOCOCCUS-AUREUS; FIBRIN SHEATH; METHICILLIN RESISTANCE; BINDING-PROTEIN; JUGULAR-VEIN; OPEN CUTDOWN; COAGULATION; INFECTION; PLACEMENT;

D O I：

10.1055/a-1695-8612

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Formation of intravenous catheter-related thrombosis leads to central venous stenosis in patients requiring renal replacement therapy or chemotherapy infusion, yet the triggers or mechanisms remain unclear, especially in patients without symptoms of infection. In this study, we found that neutrophil extracellular traps (NETs) could be detected in the fibrin sheaths from dialysis patients without clinical manifestations of infection. Confocal microscopy revealed bacteria imbedded in NETs in the fibrin sheaths. Thirty-nine of 50 (78%) fibrin sheath specimens contained bacteria detectable by 16S ribosomal RNA genome typing with a predominance of Staphylococcus aureus (69%). In rat models, transient bacteremia of S. aureus induced NETs in enlarged fibrin sheaths, and treatment with DNase I alone significantly reduced both NET and fibrin sheath formation surrounding the catheter. Therefore, transient bacteremia could be a silent trigger that induces NET-related immunothrombosis enhancing catheter-related central venous stenosis.

引用

页码：1198 / 1208

页数：11

共 58 条

[11] FIBRIN SHEATH ENTRAPMENT OF PERIPHERALLY INSERTED CENTRAL CATHETERS [J].