The microfabricated electrokinetic pump: a potential promising drug delivery technique

被引：42

作者：

Chen, Lingxin ^{[1
]}

Choot, Jaebum ^{[1
]}

Yan, Bing ^{[2
]}

机构：

[1] Hanyang Univ, Dept Appl Chem, Ansan 426791, South Korea

[2] Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Peoples R China

来源：

EXPERT OPINION ON DRUG DELIVERY | 2007年 / 4卷 / 02期

关键词：

electrokinetic pump; electroosmotic flow; electroosmotic pump; electrophoresis pump; microdosing systems;

D O I：

10.1517/17425247.4.2.119

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Directly delivering liquid using direct current power was a dream for 40 years. Now, the electrokinetic pump can accomplish it. This review reports recent developments in microfabricated electrokinetic pump technologies and their applications, and also discusses the electrophoresis pump and electroosmotic pump, as well as the materials and fabrication methods frequently used for the production of these pump devices. Electrokinetics pumps can be used to deliver pure water, pure polar organic solvents, inorganic buffer and biomacromolecules, with wide applications for the delivery of liquids. These devices have the potential to become drug delivery systems, for the precise, timed and/or targeted delivery of drugs. Future trends, limitations and possibilities are also discussed.

引用

页码：119 / 129

页数：11

共 53 条

[1] Issues and perspectives on the biocompatibility and immunotoxicity evaluation of implanted controlled release systems [J].

Anderson, JM ;

Langone, JJ .

JOURNAL OF CONTROLLED RELEASE, 1999, 57 (02) :107-113

[2] Materials science and fabrication processes for a new MEMS technoloey based on ultrananocrystalline diamond thin films [J].

Auciello, O ;

Birrell, J ;

Carlisle, JA ;

Gerbi, JE ;

Xiao, XC ;

Peng, B ;

Espinosa, HD .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2004, 16 (16) :R539-R552

[3] AC electroosmotic pump with bubble-free palladium electrodes and rectifying polymer membrane valves [J].

Brask, A ;

Snakenborg, D ;

Kutter, JP ;

Bruus, H .

LAB ON A CHIP, 2006, 6 (02) :280-288

[4] Long-term stable electroosmotic pump with ion exchange membranes [J].

Brask, A ;

Kutter, JP ;

Bruus, H .

LAB ON A CHIP, 2005, 5 (07) :730-738

[5] Theoretical analysis of the low-voltage cascade electro-osmotic pump [J].

Brask, A ;

Goranovic, G ;

Bruus, H .

SENSORS AND ACTUATORS B-CHEMICAL, 2003, 92 (1-2) :127-132

[6]

CHANG MP, 2004, WIMS ERC ANNUAL REPO, P77

[7]

CHEN, 2005, SENSOR ACTUAT B-CHEM, V104, P117

[8] Application of a high-pressure electro-osmotic pump using nanometer silica in capillary liquid chromatography [J].

Chen, LX ;

Guan, YF ;

Ma, JP ;

Luo, GA ;

Liu, KH .

JOURNAL OF CHROMATOGRAPHY A, 2005, 1064 (01) :19-24

[9] Theory, controls parameter and application of the packed-bed electroosmotic pump [J].

Chen, LX ;

Guan, YF ;

Ma, JP ;

Shu, X ;

Tan, F .

CHINESE SCIENCE BULLETIN, 2003, 48 (23) :2572-2577

[10] Generating high-pressure sub-microliter flow rate in packed microchannel by electroosmotic force: potential application in microfluidic systems [J].

Chen, LX ;

Ma, JP ;

Tan, F ;

Guan, YF .

SENSORS AND ACTUATORS B-CHEMICAL, 2003, 88 (03) :260-265

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