Study of the Catalytic Effect of Sodium Citrate on the Four-Component Synthesis of Pyrano[2,3-c] pyrazole Derivatives: An Eco-Friendly Method

被引：0
作者：
Laroum, Rima [1 ]
Boureghda, Chaima [1 ]
Benhadid, Amina [1 ]
Boulcina, Raouf [1 ]
Debache, Abdelmadjid [1 ]
机构：
[1] Univ Constantine 1, Lab Synth Mol Interets Biol, Constantine 25000, Algeria
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 03期
关键词：
Multicomponent reaction; One-pot reaction; Pyrano[2,3-c] pyrazole; Sodium citrate; Eco-friendly catalyst; ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; RAPID SYNTHESIS; IONIC LIQUID; EFFICIENT; GREEN; DOCKING;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and clean protocol was developed for the convenient synthesis of pyrano[2,3-c] pyrazoles via a one-pot four-component reaction of commercially available aldehydes, malononitrile, ethyl acetoacetate (or ethyl benzoylacetate), and hydrazine hydrate (or phenylhydrazine). The reactions were conducted in aqueous EtOH in the presence of sodium citrate as a catalyst. A series of pyrano[2,3-c] pyrazole derivatives were quickly obtained in excellent yields using this eco-friendly four-component onepot reaction.
引用
收藏
页码：295 / 301
页数：7
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