Cu-Catalyzed decarboxylative annulation of N-substituted glycines with 3-formylchromones: synthesis of functionalized chromeno[2,3-b]pyrrol-4(1H)-ones

被引：16
|
作者：
Chen, Li [1 ]
Li, Yuan-Da [1 ]
Lv, Ying [1 ]
Lu, Zi-Han [1 ]
Yan, Sheng-Jiao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resources, Minist Educ, Kunming 650091, Yunnan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 73期
关键词：
DISCOVERY; ISOCYANOACETATES; INHIBITORS; POTENT;
D O I：
10.1039/d2cc03816a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel protocol was developed for preparing functionalized chromeno[2,3-b]pyrrol-4(1H)-ones 3 (CMPOs) from 3-formylchromones with N-substituted glycine derivatives. The method entailed decarboxylative annulation of the acyl group of 3-formylchromones by simply heating a mixture of substrates 1-2 and toluene oxidized by 2-di-tert-butyl peroxide (DTBP) and catalyzed by CuBr. As a result, a series of CMPOs 3 were produced via a cascade reaction. This protocol can be used to synthesize functionalized CMPOs via combinatorial and parallel syntheses in a one-pot reaction rather than a tedious multi-step reaction.
引用
收藏
页码：10194 / 10197
页数：4
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