Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.

被引：132
作者：
Takashi, M
Mochida, K
Kozuka, M
Ito, Y
Fujiwara, Y
Hashimoto, K
Enjo, F
Ogata, M
Nobukuni, Y
Tokuda, H
Nishino, H
机构：
[1] Res Inst Prod Dev, Sakyo Ku, Kyoto 6060805, Japan
[2] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan
[3] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6020841, Japan
来源：
CANCER LETTERS | 2001年 / 172卷 / 02期
关键词：
Capsicum annuum; carotenoid; capsanthin; cancer chemopreventive activity; Epstein-Barr virus; early antigen two-stage mouse skin carcinogenesis;
D O I：
10.1016/S0304-3835(01)00635-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Capsanthin (1) and related carotenoids (2-7) isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester (3) and capsorbin diester (5) showed strong inhibitory effects. Furthermore, casanthin (1), capsanthin 3'-ester (2) and capsanthin 3,3'-diester (3), major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：103 / 109
页数：7
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