Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

被引：872

作者：

Sonoyama, Wataru ^{[3
,4
]}

Liu, Yi ^{[1
,2
]}

Fang, Dianji ^{[1
,2
]}

Yamaza, Takayoshi ^{[3
]}

Seo, Byoung-Moo ^{[5
]}

Zhang, Chunmei ^{[1
,2
]}

Liu, He ^{[6
]}

Gronthos, Stan ^{[7
]}

Wang, Cun-Yu ^{[8
,9
]}

Shi, Songtao ^{[1
,2
]}

Wang, Songlin ^{[3
]}

机构：

[1] Capital Med Univ, Sch Stomatol, Salivary Gland Dis Ctr, Beijing, Peoples R China

[2] Capital Med Univ, Sch Stomatol, Mol Lab Gene Therapy, Beijing, Peoples R China

[3] Univ So Calif, Ctr Craniofacial Mol Biol, Sch Dent, Los Angeles, CA 90033 USA

[4] Okayama Univ, Dept Oral & Maxillofacial Rehabil, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[5] Seoul Natl Univ, Dept Oral & Maxillofacial Rehabil, Sch Dent, Dent Res Inst, Seoul, South Korea

[6] Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China

[7] Inst Med & Vet Sci, Div Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA 5000, Australia

[8] Univ Michigan, Lab Mol Signaling & Apoptosis, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

[9] Univ Michigan, Program Mol & Cellular Biol, Ann Arbor, MI 48109 USA

来源：

PLOS ONE | 2006年 / 1卷 / 01期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

D O I：

10.1371/journal.pone.0000079

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

引用

页数：8

共 21 条

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