Galectin-3 in cord blood of term and preterm infants

被引：19
作者：
Demmert, M.
Faust, K.
Bohlmann, M. K. [2 ]
Troeger, B.
Goepel, W.
Herting, E.
Haertel, C. [1 ]
机构：
[1] Univ Lubeck, Sch Med, Dept Paediat, D-23538 Lubeck, Germany
[2] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Lubeck, Germany
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 02期
关键词：
cord blood; galectin-3; Group B Streptococcus; FOR-GESTATIONAL-AGE; HOST INFLAMMATORY RESPONSE; HUMAN NEUTROPHILS; CANDIDA-ALBICANS; NEWBORN-INFANTS; BINDING-PROTEIN; CELL-DEATH; EXPRESSION; GROWTH; STREPTOCOCCUS;
D O I：
10.1111/j.1365-2249.2011.04509.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of term and preterm neonates as well as galectin-3 levels in cord blood of term neonates after stimulation with the prevalent pathogen Streptococcus agalactiae. Cord blood samples were incubated for 24 h and galectin-3 levels were assessed by enzyme-linked immunosorbent assay. There is a positive correlation between gestational age and galectin-3 levels in cord blood. Expression of galectin-3 is significantly higher in cord blood of small-for-gestational-age infants compared to appropriate-for-gestational-age infants. Stimulation with an invasive but not with a colonizing strain of S. agalactiae induced expression of galectin-3. Galectin-3 is expressed constitutively in cord blood of neonates and seems to play a role in the innate immunity of this population.
引用
收藏
页码：246 / 251
页数：6
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