Galectin-3 in cord blood of term and preterm infants

被引：19
作者：
Demmert, M.
Faust, K.
Bohlmann, M. K. [2 ]
Troeger, B.
Goepel, W.
Herting, E.
Haertel, C. [1 ]
机构：
[1] Univ Lubeck, Sch Med, Dept Paediat, D-23538 Lubeck, Germany
[2] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Lubeck, Germany
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 02期
关键词：
cord blood; galectin-3; Group B Streptococcus; FOR-GESTATIONAL-AGE; HOST INFLAMMATORY RESPONSE; HUMAN NEUTROPHILS; CANDIDA-ALBICANS; NEWBORN-INFANTS; BINDING-PROTEIN; CELL-DEATH; EXPRESSION; GROWTH; STREPTOCOCCUS;
D O I：
10.1111/j.1365-2249.2011.04509.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of term and preterm neonates as well as galectin-3 levels in cord blood of term neonates after stimulation with the prevalent pathogen Streptococcus agalactiae. Cord blood samples were incubated for 24 h and galectin-3 levels were assessed by enzyme-linked immunosorbent assay. There is a positive correlation between gestational age and galectin-3 levels in cord blood. Expression of galectin-3 is significantly higher in cord blood of small-for-gestational-age infants compared to appropriate-for-gestational-age infants. Stimulation with an invasive but not with a colonizing strain of S. agalactiae induced expression of galectin-3. Galectin-3 is expressed constitutively in cord blood of neonates and seems to play a role in the innate immunity of this population.
引用
收藏
页码：246 / 251
页数：6
相关论文
共 42 条
[1]   Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes [J].
Ahmad, N ;
Gabius, HJ ;
André, S ;
Kaltner, H ;
Sabesan, S ;
Roy, R ;
Liu, BC ;
Macaluso, F ;
Brewer, CF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (12) :10841-10847
[2]   Increased cord serum inflammatory markers in small-for-gestational-age neonates [J].
Amarilyo, G. ;
Oren, A. ;
Mimouni, F. B. ;
Ochshorn, Y. ;
Deutsch, V. ;
Mandel, D. .
JOURNAL OF PERINATOLOGY, 2011, 31 (01) :30-32
[3]  
BARONDES SH, 1994, J BIOL CHEM, V269, P20807
[4]   Different cytokine expression in cord blood mononuclear cells after stimulation with neonatal sepsis or colonizing strains of Streptococcus agalactiae [J].
Berner, R ;
Csorba, J ;
Brandis, M .
PEDIATRIC RESEARCH, 2001, 49 (05) :691-697
[5]   Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice [J].
Colnot, C ;
Ripoche, MA ;
Milon, G ;
Montagutelli, X ;
Crocker, PR ;
Poirier, F .
IMMUNOLOGY, 1998, 94 (03) :290-296
[6]   IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF GALECTIN-3, AN IGE BINDING-PROTEIN, IN HUMAN MAST-CELLS AND BASOPHILS [J].
CRAIG, SS ;
KRISHNASWAMY, P ;
IRANI, AMA ;
KEPLEY, CL ;
LIU, FT ;
SCHWARTZ, LB .
ANATOMICAL RECORD, 1995, 242 (02) :211-219
[7]  
Doverhag C, 2010, INFLAMMATORY MECH EX
[8]   Expression of galectin-3 in cells exposed to stress -: roles of Jun and NF-κB [J].
Dumic, J ;
Lauc, G ;
Flögel, M .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2000, 10 (03) :149-158
[9]   Mechanisms of Disease: Hypoxia and Inflammation. [J].
Eltzschig, Holger K. ;
Carmeliet, Peter .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (07) :656-665
[10]   Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function [J].
Farnworth, Sarah L. ;
Henderson, Neil C. ;
MacKinnon, Alison C. ;
Atkinson, Kirsten M. ;
Wilkinson, Tom ;
Dhaliwal, Kevin ;
Hayashi, Katsutoshi ;
Simpson, A. John ;
Rossi, Adriano G. ;
Haslett, Christopher ;
Sethi, Tariq .
AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (02) :395-405
12345