Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines.: X-ray crystal structure of trans-[ PtCl2{Z-N(H)=C(NHMe)CH2Ph}2]

被引：19
作者：
Sbovata, Silvia Mazzega [1 ]
Bettio, Frazia [2 ]
Marzano, Christine [2 ]
Mozzon, Mirto [1 ]
Bertani, Roberta [1 ]
Benetollo, Franco [3 ]
Michelin, Rino A. [1 ]
机构：
[1] Univ Padua, Dept Chem Proc Engn, I-35131 Padua, Italy
[2] Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy
[3] CNR, ICIS, I-35127 Padua, Italy
来源：
INORGANICA CHIMICA ACTA | 2008年 / 361卷 / 11期
关键词：
amidine complexes; platinum(II); cytotoxic activity; crystal structure;
D O I：
10.1016/j.ica.2007.10.054
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The reaction of cis- and trans-[PtCl(2)(NCCH(2)Ph)(2)] with a 5-fold excess of MeNH(2) and Me(2)NH in CH(2)Cl(2) at -10 degrees C affords in high yield the bis-amidine derivatives cis- and trans-[PtCl(2){Z-N(H)=C(NHMe)CH(2)Ph}(2)] (1a, 2a) and cis- and trans-[PtCl(2){EN(H)=C(NMe(2))CH(2)Ph}(2)] (3a, 4a), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans-[PtCl(2){Z-N(H)=C(NHMe)CH(2)Ph}(2)] (2a). Moreover, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines. (c) 2008 Elsevier B.V. All rights reserved.
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收藏
页码：3109 / 3116
页数：8
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