Preparation, characterization, and application of multistimuli-responsive microspheres with fluorescence-labeled magnetic cores and thermoresponsive shells

被引：147
作者：
Deng, YH
Wang, CC
Shen, XZ
Yang, WL
An, L
Gao, H
Fu, SK [1 ]
机构：
[1] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 20期
关键词：
core-shell structures; drug carriers; fluorescence; magnetic properties; thermoresponsive;
D O I：
10.1002/chem.200500605
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel functional microspheres with multistimuli-responsive properties have been prepared and characterized. The as-prepared microspheres respond to an external magnetic field, environmental temperature, and ultraviolet radiation. The in vitro drug-loading efficiency and drug-released behavior of these microspheres demonstrated that they could be used as drug carriers for drug controlled release. The results of in vivo distribution investigations of these microspheres showed that they exhibit a high magnetic-targeting effect, which holds promise for applications in various fields such as magnetic drug targeting and tissue labeling, among others.
引用
收藏
页码：6006 / 6013
页数：8
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