Diencephalic and brainstem mechanisms in migraine

被引:383
作者
Akerman, Simon [1 ]
Holland, Philip R. [1 ,2 ]
Goadsby, Peter J. [1 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Neurol, Headache Grp, San Francisco, CA 94115 USA
[2] Univ Edinburgh, Ctr Neuroregenerat, Edinburgh EH16 4SB, Midlothian, Scotland
[3] UCSF Headache Ctr, San Francisco, CA 94115 USA
基金
英国医学研究理事会;
关键词
CORTICAL SPREADING DEPRESSION; GENE-RELATED PEPTIDE; SUPERIOR SAGITTAL SINUS; CEREBRAL BLOOD-FLOW; ROSTRAL VENTROMEDIAL MEDULLA; CERVICAL-SPINAL-CORD; FAMILIAL HEMIPLEGIC MIGRAINE; RANDOMIZED CONTROLLED-TRIAL; CALCIUM-CHANNEL BLOCKADE; CGRP RECEPTOR ANTAGONIST;
D O I
10.1038/nrn3057
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Migraine is a common and complex brain disorder. Although it is clear that head pain is a key manifestation of the disorder for most patients, what drives the activation of neuronal pain pathways in susceptible patients is less obvious. There is growing evidence that migraine pathophysiology may, in part, include dysfunction of subcortical structures. These include diencephalic and brainstem nuclei that can modulate the perception of activation of the trigeminovascular system, which carries sensory information from the cranial vasculature to the brain. Dysfunction of these nuclei, and their connections to other key brain centres, may contribute to the cascade of events that results in other symptoms of migraine - such as light and sound sensitivity - thus providing a comprehensive explanation of the neurobiology of the disorder.
引用
收藏
页码:570 / 584
页数:15
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