Mast cells as sentinels of innate immunity

被引：317

作者：

Galli, SJ ^{[1
]}

Maurer, M ^{[1
]}

Lantz, CS ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr E, Dept Pathol, Div Expt Pathol, Boston, MA 02215 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)80010-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells are widely regarded as important effector cells in immune responses associated with Th2 cells and IgE. Recent work shows that they can also contribute significantly to the expression of innate immunity; furthermore, survival in a model of acute bacterial infection that is dependent on complement and mast cells can be greatly enhanced by long-term treatment of mice with the kit ligand (stem cell factor) at least in part because of the effects of such treatment on mast cell numbers and/or function. These findings not only indicate that mast cells can represent a critical component of host defense in natural immunity but also suggest that mast cell function in this setting can be manipulated for therapeutic ends.

引用

页码：53 / 59

页数：7

共 71 条

[1] Mast cells in infection and immunity [J].

Abraham, SN ;

Malaviya, R .

INFECTION AND IMMUNITY, 1997, 65 (09) :3501-3508

[2]

ADUSU TE, 1994, CAN J VET RES, V58, P1

[3] MOLECULAR-CLONING OF MAST-CELL GROWTH-FACTOR, A HEMATOPOIETIN THAT IS ACTIVE IN BOTH MEMBRANE-BOUND AND SOLUBLE FORMS [J].

ANDERSON, DM ;

LYMAN, SD ;

BAIRD, A ;

WIGNALL, JM ;

EISENMAN, J ;

RAUCH, C ;

MARCH, CJ ;

BOSWELL, HS ;

GIMPEL, SD ;

COSMAN, D ;

WILLIAMS, DE .

CELL, 1990, 63 (01) :235-243

[4] EFFECTS OF CHRONIC TREATMENT WITH THE C-KIT LIGAND, STEM-CELL FACTOR, ON IMMUNOGLOBULIN-E DEPENDENT ANAPHYLAXIS IN MICE - GENETICALLY MAST-CELL DEFICIENT SL/SL(D) MICE ACQUIRE ANAPHYLACTIC RESPONSIVENESS, BUT THE CONGENIC NORMAL MICE DO NOT EXHIBIT AUGMENTED RESPONSES [J].

ANDO, A ;

MARTIN, TR ;

GALLI, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1639-1649

[5]

ANSEL JC, 1993, J IMMUNOL, V150, P4478

[6]

ARIZONO N, 1993, BLOOD, V81, P2572

[7] Lung granulomatous response induced by infection with the intestinal nematode Nippostrongylus brasiliensis is suppressed in mast cell-deficient Ws/Ws rats [J].

Arizono, N ;

Nishida, M ;

Uchikawa, R ;

Yamada, M ;

Matsuda, S ;

Tegoshi, T ;

Kitamura, Y ;

Sasabe, M .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 106 (01) :55-61

[8] SIGNAL-TRANSDUCTION BY FC-RECEPTORS - THE FC-EPSILON-RI CASE [J].

BEAVEN, MA ;

METZGER, H .

IMMUNOLOGY TODAY, 1993, 14 (05) :222-226

[9] Evidence for direct interaction between mast cells and Leishmania parasites [J].

Bidri, M ;

Vouldoukis, I ;

Mossalayi, MD ;

Debre, P ;

Guillosson, JJ ;

Mazier, D ;

Arock, M .

PARASITE IMMUNOLOGY, 1997, 19 (10) :475-483

[10] ANAPHYLAXIS [J].

BOCHNER, BS ;

LICHTENSTEIN, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (25) :1785-1790

← 1 2 3 4 5 6 7 8 →