Cemiplimab in Advanced Cutaneous Squamous Cell Carcinoma: Real-World Experience in a Monographic Oncology Center

被引：0

作者：

Rios-Vinuela, E. ^{[1
]}

Alvarez, P. ^{[2
]}

Lavernia, J. ^{[2
]}

Serra-Guillen, C. ^{[1
]}

Requena, C. ^{[1
]}

Bernia, E. ^{[1
]}

Diago, A. ^{[3
]}

Llombart, B. ^{[1
]}

Sanmartin, O. ^{[1
]}

机构：

[1] Inst Valenciano Oncol, Dept Dermatol, Valencia, Spain

[2] Inst Valenciano Oncol, Dept Oncol, Valencia, Spain

[3] Hosp Univ Miguel Servet, Dept Dermatol, Zaragoza, Spain

来源：

ACTAS DERMO-SIFILIOGRAFICAS | 2022年 / 113卷 / 06期

关键词：

Advanced cutaneous squamous cell carcinoma; Metastatic squamous cell carcinoma; Locally-advanced squamous cell carcinoma; Cemiplimab; PD-1; inhibitorsefficacy;

D O I：

10.1016/j.ad.2022.05.001

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Management of advanced cSCC is challenging, and many available systemic medications have modest efficacy. Cemiplimab has demonstrated efficacy in the treatment of advanced cSCC in clinical trials, but real-world data are still limited. With the objective of evaluating the efficacy of cemiplimab in a real-world clinical setting, we conducted a prospective observational study of 13 patients with advanced cSCC. Six patients (46%) had locally advanced disease, while 7 (54%) had metastatic disease. A total of 8 patients (62%) responded to cemiplimab. Five (38%) showed a partial response, while 3 (23%) showed a complete response. Four patients with an initial partial response presented subsequent disease progression during follow-up. Six patients (46%) developed AEs, most of which were mild (G1). PFS was 5.9 months, with a median follow-up was 9 months. In conclusion, cemiplimab demonstrated its utility in the treatment of advanced cSCC, with acceptable response rates, a remarkable number of complete responses, and a very good safety profile. (C) 2022 Published by Elsevier Espana, S.L.U. on behalf of AEDV.

引用

页码：T610 / T615

页数：6

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