Stem Cells for Improving the Treatment of Neurodevelopmental Disorders

被引：6
|
作者：
Donegan, Jennifer J. [1 ,2 ]
Lodge, Daniel J. [1 ,2 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, Mail Code 7764,7703 Floyd Curl Dr, San Antonio, TX 78229 USA
[2] Univ Texas Hlth Sci Ctr San Antonio, Ctr Biomed Neurosci, San Antonio, TX 78229 USA
来源：
STEM CELLS AND DEVELOPMENT | 2020年 / 29卷 / 17期
关键词：
schizophrenia; autism; IPSC; neurons; organoids; GLUTAMIC-ACID DECARBOXYLASE; DOPAMINE SYNTHESIS CAPACITY; AUTISM SPECTRUM; GENE-EXPRESSION; HIPPOCAMPAL-FORMATION; ANTIPSYCHOTIC-DRUGS; PRENATAL INFECTION; MATERNAL INFECTION; CORTICAL-NEURONS; SYSTEM FUNCTION;
D O I：
10.1089/scd.2019.0265
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Treatment options for neurodevelopmental disorders such as schizophrenia and autism are currently limited. Antipsychotics used to treat schizophrenia are not effective for all patients, do not target all symptoms of the disease, and have serious adverse side effects. There are currently no FDA-approved drugs to treat the core symptoms of autism. In an effort to develop new and more effective treatment strategies, stem cell technologies have been used to reprogram adult somatic cells into induced pluripotent stem cells, which can be differentiated into neuronal cells and even three-dimensional brain organoids. This new technology has the potential to elucidate the complex mechanisms that underlie neurodevelopmental disorders, offer more relevant platforms for drug discovery and personalized medicine, and may even be used to treat the disease.
引用
收藏
页码：1118 / 1130
页数：13
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