Gait and axial postural abnormalities correlations in Parkinson's disease: A multicenter quantitative study

被引：9

作者：

Pongmala, Chatkaew ^{[1
,2
]}

Fabbri, Margherita ^{[3
,4
]}

Zibetti, Maurizio ^{[1
]}

Pitakpatapee, Yuvadee ^{[5
]}

Wangthumrong, Takarn ^{[5
]}

Sangpeamsook, Tanita ^{[5
]}

Srikajon, Jindapa ^{[5
]}

Srivanitchapoom, Prachaya ^{[5
]}

Youn, Jinyoung ^{[6
,7
]}

Cho, Jin Whan ^{[6
,7
]}

Kim, Minkyeong ^{[8
]}

Shinawi, Heba M. Zamil ^{[9
]}

Obaid, Mona Talib ^{[9
]}

Baumanni, Alexander ^{[10
]}

Margraf, Nils G. ^{[10
,11
]}

Pona-Ferreiraj, Filipa ^{[11
]}

Leitaoj, Mariana ^{[11
]}

Loboj, Teresa ^{[11
]}

Ferreiraj, Joaquim J. ^{[12
]}

Lopiano, Leonardo ^{[1
]}

Artusi, Carlo Alberto ^{[1
]}

机构：

[1] Univ Turin, Dept Neurosci Levi Montalcini Rita Levi Montalcini, Via Cherasco 15, I-10124 Turin, Italy

[2] Univ Michigan, Dept Radiol, Ann Arbor, MI USA

[3] Univ Toulouse 3, Toulouse Univ Hosp,INSERM, Dept Neurosci,Clin Invest Ctr CIC 1436, Parkinson Toulouse Expert Ctr,NS Pk FCRIN Network, Toulouse, France

[4] Univ Toulouse 3, Toulouse Univ Hosp, NeuroToul COEN Ctr, INSERM, Toulouse, France

[5] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Med,Div Neurol, Bangkok, Thailand

[6] Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea

[7] Samsung Med Ctr, Neurosci Ctr, Seoul, South Korea

[8] Gyeongsang Natl Univ Hosp, Dept Neurol, Jinju, South Korea

[9] King Fahad Med City, Natl Neurosci Inst, Riyadh, Saudi Arabia

[10] Inst Med Mol Joao Lobo Antunes, Dept Neurol, Campus Kiel, Kiel, Portugal

[11] CNS Campus Neurol, Torres Vedras, Portugal

[12] Univ Lisbon, Fac Med, Lab Clin Pharmacol & Therapeut, Lisbon, Portugal

来源：

PARKINSONISM & RELATED DISORDERS | 2022年 / 105卷

关键词：

Gait; Axial posture; Parkinson ?s disease; Postural abnormalities; PISA SYNDROME;

D O I：

10.1016/j.parkreldis.2022.10.026

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Gait and axial postural abnormalities (PA) are common and disabling symptoms of Parkinson's disease (PD). The interplay between them has been poorly explored.Methods: A standardized protocol encompassing videos and photos for posture and gait analysis of PD patients with a clinically defined PA (MDS-UPDRS-III item 3.13 > 0) was used in 6 movement disorder centers. A comprehensive evaluation was performed to clarify the association between gait performance and the presence and severity of PA.Results: 225 PD patients were enrolled: 57 had severe PA, 149 mild PA, and 19 did not meet criteria for PA, according to a recent consensus agreement on PA definition. PD patients with severe PA were significantly older (p:0.001), with longer disease duration (p:0.007), worse MDS-UPDRS-II and -III scores and axial sub-scores (p < 0.0005), higher LEDD (p:0.002) and HY stage (p < 0.0005), and a significantly lower velocity (p < 0.001) and cadence (p:0.021), if compared to mild PA patients. The multiple regression analysis evaluating gait parameters and degrees of trunk/neck flexion showed that higher degrees of lumbar anterior trunk flexion were correlated with lower step length (OR-0.244; p:0.014) and lower velocity (OR-0.005; p:0.028).Conclusions: Our results highlight the possible impact of severe anterior trunk flection on PD patients' gait, with a specific detrimental effect on gait velocity and step length. Personalized rehabilitation strategies should be elaborated based on the different features of PA, aiming to target a combined treatment of postural and spe-cifically related gait pattern alterations.

引用

页码：19 / 23

页数：5

共 14 条

[1] A systematic review on the effectiveness of perturbation-based balance training in postural control and gait in Parkinson's disease [J].