Rhodium-catalyzed asymmetric 1,6-addition of aryltitanates to enynones giving axially chiral allenes

被引：116

作者：

Hayashi, T ^{[1
]}

Tokunaga, N ^{[1
]}

Inoue, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1021/ol036309f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The addition of aryltitanate reagents ArTi(OPr-i)(4)Li to 3-alkynyl-2-en-1-ones in the presence of chlorotrimethylsilane and a rhodium-(R)-segphos as a catalyst proceeded in a 1,6-fashion to give a high yield of axially chiral allenylalkenyl silyl enol ethers with up to 93% ee.

引用

页码：305 / 307

页数：3

共 40 条

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