Association between intestinal microbiota and inflammatory bowel disease

被引:63
作者
Zhang, Yunchang [1 ]
Si, Xuemeng [2 ,3 ]
Yang, Ling [4 ]
Wang, Hui [4 ]
Sun, Ye [5 ,6 ]
Liu, Ning [2 ,3 ]
机构
[1] Chinese Acad Agr Sci, Inst Feed Res, Minist Agr & Rural Affairs, Beijing, Peoples R China
[2] China Agr Univ, Dept Anim Nutr & Feed Sci, State Key Lab Anim Nutr, Beijing, Peoples R China
[3] China Agr Univ, Dept Nutr & Hlth, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China
[4] Beijing Vocat Coll Agr, Dept Food & Bioengn, Beijing, Peoples R China
[5] Chinese Acad Med Sci, Inst Med Lab Anim Sci, Beijing 100021, Peoples R China
[6] Peking Union Med Coll, Comparat Med Ctr, Beijing 100021, Peoples R China
基金
中国国家自然科学基金;
关键词
dysbiosis; IBD model; intestinal microbiota; metabolites; CITROBACTER-RODENTIUM INFECTION; BUTYRATE-PRODUCING BACTERIA; ULCERATIVE-COLITIS; GUT MICROBIOTA; GERM-FREE; DEXTRAN SULFATE; ANIMAL-MODELS; ESCHERICHIA-COLI; IMMUNE-RESPONSES; FECAL MICROBIOTA;
D O I
10.1002/ame2.12255
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), has emerged as a global disease with high incidence, long duration, devastating clinical symptoms, and low curability (relapsing immune response and barrier function defects). Mounting studies have been performed to investigate its pathogenesis to provide an ever-expanding arsenal of therapeutic options, while the precise etiology of IBD is not completely understood yet. Recent advances in high-throughput sequencing methods and animal models have provided new insights into the association between intestinal microbiota and IBD. In general, dysbiosis characterized by an imbalanced microbiota has been widely recognized as a pathology of IBD. However, intestinal microbiota alterations represent the cause or result of IBD process remains unclear. Therefore, more evidences are needed to identify the precise role of intestinal microbiota in the pathogenesis of IBD. Herein, this review aims to outline the current knowledge of commonly used, chemically induced, and infectious mouse models, gut microbiota alteration and how it contributes to IBD, and dysregulated metabolite production links to IBD pathogenesis.
引用
收藏
页码:311 / 322
页数:12
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