An in situ Raman spectroscopy-based microfluidic "lab-on-a-chip" platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms

被引：34

作者：

Feng, Jinsong ^{[1
]}

de la Fuente-Nunez, Cesar ^{[2
]}

Trimble, Michael J. ^{[2
]}

Xu, Jie ^{[3
]}

Hancock, Robert E. W. ^{[2
]}

Lu, Xiaonan ^{[1
]}

机构：

[1] Univ British Columbia, Food Nutr & Hlth Program, Fac Land & Food Syst, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Ctr Microbial Dis & Immun Res, Vancouver, BC V6T 1Z4, Canada

[3] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 43期

基金：

美国国家卫生研究院; 加拿大自然科学与工程研究理事会;

关键词：

BACTERIAL BIOFILMS; DEVICE; ENVIRONMENT; RESISTANCE; DYNAMICS;

D O I：

10.1039/c5cc02744f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pseudomonas aeruginosa biofilm was cultivated and characterized in a microfluidic "lab-on-a-chip" platform coupled with confocal Raman microscopy in a non-destructive manner. Biofilm formation could be quantified by this label-free platformand correlated well with confocal laser scanning microscopy. This Raman-microfluidic platform could also discriminate biofilms at different developmental stages.

引用

页码：8966 / 8969

页数：4

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