MicroRNAs in Oligodendrocyte and Schwann Cell Differentiation

被引：40

作者：

Dugas, Jason C. ^{[1
]}

Notterpek, Lucia ^{[2
]}

机构：

[1] Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA

[2] Univ Florida, Coll Med, Dept Neurosci, McKnight Brain Inst, Gainesville, FL 32610 USA

来源：

DEVELOPMENTAL NEUROSCIENCE | 2011年 / 33卷 / 01期

基金：

美国国家卫生研究院;

关键词：

miRNA; Oligodendrocyte; Schwann cell; Myelin; CENTRAL-NERVOUS-SYSTEM; LAMIN B1; DICER; MYELINATION; AUTOANTIBODIES; ASTROCYTES; EXPRESSION; BODIES; GAMMA;

D O I：

10.1159/000323919

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs (miRNAs) are a class of small (approx. 22 nt) noncoding RNAs that are capable of post-transcriptionally silencing mRNAs that contain sequences complementary to the miRNAs' 7- to 8-bp 'seed' sequence. As single miRNAs are often predicted to target up to hundreds of individual transcripts, miRNAs are able to broadly affect the overall protein expression state of the cell. This can translate into global effects on cellular health and differentiation state. Recently, several reports have identified crucial roles for miRNAs in controlling the production, differentiation, and health of myelinating cells of the mammalian nervous system. In this review, we will discuss how individual miRNAs regulate these various processes, and also how miRNA production in general is required for several stages of myelin generation and maintenance. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：14 / 20

页数：7

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