Prognostic Value of the Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Patients with Neuroendocrine Tumors: An Izmir Oncology Group Study

被引：49

作者：

Salman, Tarik ^{[1
]}

Kazaz, Seher Nazli ^{[2
]}

Varol, Umut ^{[1
]}

Oflazoglu, Utku ^{[1
]}

Unek, Ilkay Tugba ^{[2
]}

Kucukzeybek, Yuksel ^{[1
]}

Alacacioglu, Ahmet ^{[1
]}

Atag, Elif ^{[2
]}

Semiz, Huseyin Salih ^{[2
]}

Cengiz, Hakan ^{[4
]}

Oztop, Ilhan ^{[2
]}

Tarhan, Mustafa Oktay ^{[3
]}

机构：

[1] Izmir Katip Celebi Univ, Ataturk Res & Training Hosp, Dept Med Oncol, Hasan Tahsin St 105, TR-35360 Izmir, Turkey

[2] Dokuz Eylul Univ, Fac Med, Dept Med Oncol, Izmir, Turkey

[3] Dokuz Eylul Univ, Inst Oncol, Izmir, Turkey

[4] Sifa Univ, Fac Med, Dept Biostat, Izmir, Turkey

来源：

CHEMOTHERAPY | 2015年 / 61卷 / 06期

关键词：

Neuroendocrine tumors; Neutrophil-lymphocyte ratio; Platelet-lymphocyte ratio; CARCINOID-TUMORS; CELLS; INFLAMMATION; RESECTION; SURVIVAL;

D O I：

10.1159/000445045

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Several studies evaluating the prognostic factors of gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) have been published. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been accepted as prognostic factors for cancer patients. Materials and Methods: This study included 132 patients diagnosed with GEP-NETs. Peripheral blood samples were collected before the pretreatment period. Results: NLR and PLR were increased as the grade increased in NETs. The embryonic origin analysis revealed higher NLR and PLR rates in NETs of foregut origin. NLR and PLR were also higher in pancreatic NET patients compared to the gastroenteric NET patients. Analysis of NETs by TNM indicated that an advanced stage was accompanied by significantly higher NLR and PLR. We found a strong negative correlation between progression-free survival and NLR and PLR. Conclusion: The study verified that NLR and PLR are simple laboratory findings that can be used to identify NETs with a worse outcome. (C) 2016 S. Karger AG, Basel.

引用

页码：281 / 286

页数：6

共 31 条

[1] Interleukin 1β Gene Single-Nucleotide Polymorphisms and Susceptibility to Pancreatic Neuroendocrine Tumors [J].

Berkovic, Maja Cigrovski ;

Ivkovic, Tina Catela ;

Marout, Jasminka ;

Zjacic-Rotkvic, Vanja ;

Kapitanovic, Sanja .

DNA AND CELL BIOLOGY, 2012, 31 (04) :531-536

[2] NFKB1-94 Insertion/Deletion ATTG Polymorphism in Gastroenteropancreatic Neuroendocrine Tumors [J].

Burnik, Ferda Sevimli ;

Yalcin, Suayib .

CHEMOTHERAPY, 2009, 55 (05) :381-385

[3] Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet? [J].

Coussens, Lisa M. ;

Zitvogel, Laurence ;

Palucka, A. Karolina .

SCIENCE, 2013, 339 (6117) :286-291

[4] Platelets at the interface of thrombosis, inflammation, and cancer [J].

Franco, Aime T. ;

Corken, Adam ;

Ware, Jerry .

BLOOD, 2015, 126 (05) :582-588

[5] Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE) [J].

Garcia-Carbonero, R. ;

Capdevila, J. ;

Crespo-Herrero, G. ;

Diaz-Perez, J. A. ;

Martinez del Prado, M. P. ;

Alonso Orduna, V. ;

Sevilla-Garcia, I. ;

Villabona-Artero, C. ;

Beguiristain-Gomez, A. ;

Llanos-Munoz, M. ;

Marazuela, M. ;

Alvarez-Escola, C. ;

Castellano, D. ;

Vilar, E. ;

Jimenez-Fonseca, P. ;

Teule, A. ;

Sastre-Valera, J. ;

Benavent-Vinuelas, M. ;

Monleon, A. ;

Salazar, R. .

ANNALS OF ONCOLOGY, 2010, 21 (09) :1794-1803

[6] Platelets Effects on Tumor Growth [J].

Goubran, Hadi A. ;

Stakiw, Julie ;

Radosevic, Mirjana ;

Bumouf, Thierry .

SEMINARS IN ONCOLOGY, 2014, 41 (03) :359-369

[7] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[8] Pancreatic Neuroendocrine Tumors [J].

Hill, Joshua S. ;

McPhee, James T. ;

McDade, Theodore P. ;

Zhou, Zheng ;

Sullivan, Mary E. ;

Whalen, Giles F. ;

Tseng, Jennifer F. .

CANCER, 2009, 115 (04) :741-751

[9] T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases [J].

Katz, Steven C. ;

Donkor, Charan ;

Glasgow, Kristen ;

Pillarisetty, Venu G. ;

Goenen, Mithat ;

Espat, N. Joseph ;

Klimstra, David S. ;

D'Angelica, Michael I. ;

Allen, Peter J. ;

Jarnagin, William ;

DeMatteo, Ronald P. ;

Brennan, Murray F. ;

Tang, Laura H. .

HPB, 2010, 12 (10) :674-683

[10] Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms [J].

La Rosa, Stefano ;

Inzani, Frediano ;

Vanoli, Alessandro ;

Klersy, Catherine ;

Dainese, Linda ;

Rindi, Guido ;

Capella, Carlo ;

Bordi, Cesare ;

Solcia, Enrico .

HUMAN PATHOLOGY, 2011, 42 (10) :1373-1384

← 1 2 3 4 →