The dynamic structure of the germinal center

被引：128

作者：

Camacho, SA

Kosco-Vilbois, MH

Berek, C

机构：

[1] Deutsch Rheuma Forschungszentrum, D-10117 Berlin, Germany

[2] Serono Pharmaceut Res Inst, CH-1228 Geneva, Switzerland

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(98)01327-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.

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页码：511 / 514

页数：4

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