Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain

被引：1

作者：

Gao, Liangcai ^{[1
]}

Liu, Xinnan ^{[1
]}

Yu, Li ^{[1
]}

Wu, Junlin ^{[1
]}

Xu, Mingchu ^{[1
,2
]}

Liu, Yusi ^{[1
]}

机构：

[1] East China Normal Univ, Sch Life Sci, Dept Biomed Sci, Shanghai, Peoples R China

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

NEUROREPORT | 2017年 / 28卷 / 16期

关键词：

antidepressant; brain-derived neurotrophic factor; folic acid; glutamate receptor 1; CHRONIC MILD STRESS; MONOAMINE-DEFICIENCY; FOLATE METABOLISM; ANIMAL-MODEL; DEPRESSION; RATS; BDNF; MICE; FLUOXETINE; HIPPOCAMPUS;

D O I：

10.1097/WNR.0000000000000887

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Folic acid is a vitamin with a variety of pharmacological effects. The present study aims to explore the beneficial effects of folic acid on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors and its possible mechanisms. The behavioral tests including open-field test, tail suspension test, and forced swimming test were used to evaluate the antidepressant effects of folic acid. Then the changes of brain 5-hydroxytryptamine (5-HT) concentration, brain-derived neurotrophic factor (BDNF), glutamate receptor 1 (GluR1) expression levels, and synaptic organization were assessed to explore the antidepressant mechanisms of folic acid. Our results showed that CUMS caused significant depression-like behaviors, neuropathological changes, and decreased brain 5-HT concentration, BDNF, and GluR1 expression in the hippocampus and association cortex. In conclusion, the results showed that folic acid significantly improved depression-like behaviors in CUMS-induced rats, and its antidepressant effects might be related to the increase of brain 5-HT concentration, BDNF and GluR1 expression, and repair of synaptic organization in the brain. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：1078 / 1084

页数：7

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