Three-dimensional numerical simulation and experimental investigation of boundary-driven streaming in surface acoustic wave microfluidics

被引:50
作者
Chen, Chuyi [1 ]
Zhang, Steven Peiran [1 ]
Mao, Zhangming [2 ]
Nama, Nitesh [2 ]
Gu, Yuyang [1 ]
Huang, Po-Hsun [1 ]
Jing, Yun [3 ]
Guo, Xiasheng [4 ]
Costanzo, Francesco [2 ]
Huang, Tony Jun [1 ]
机构
[1] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27707 USA
[2] Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA
[3] North Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA
[4] Nanjing Univ, Dept Phys, Collaborat Innovat Ctr Adv Microstruct, Key Lab Modern Acoust MOE, Nanjing 210093, Jiangsu, Peoples R China
基金
美国国家科学基金会; 中国国家自然科学基金; 美国国家卫生研究院;
关键词
SINGLE CELLS; MANIPULATION; RADIATION; TRANSPORT; PATTERNS; MOTION;
D O I
10.1039/c8lc00589c
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Acoustic streaming has been widely used in microfluidics to manipulate various micro-/nano-objects. In this work, acoustic streaming activated by interdigital transducers (IDT) immersed in highly viscous oil is studied numerically and experimentally. In particular, we developed a modeling strategy termed the slip velocity method that enables a 3D simulation of surface acoustic wave microfluidics in a large domain (4 x 4 x 2 mm(3)) and at a high frequency (23.9 MHz). The experimental and numerical results both show that on top of the oil, all the acoustic streamlines converge at two horizontal stagnation points above the two symmetric sides of the IDT. At these two stagnation points, water droplets floating on the oil can be trapped. Based on these characteristics of the acoustic streaming field, we designed a surface acoustic wave microfluidic device with an integrated IDT array fabricated on a 128 degrees YX LiNbO3 substrate to perform programmable, contactless droplet manipulation. By activating IDTs accordingly, the water droplets on the oil can be moved to the corresponding traps. With its excellent capability for manipulating droplets in a highly programmable, controllable manner, our surface acoustic wave microfluidic devices are valuable for on-chip contactless sample handling and chemical reactions.
引用
收藏
页码:3645 / 3654
页数:10
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