Continuous-flow production of polymeric micelles in microreactors: Experimental and computational analysis

被引：38

作者：

Capretto, Lorenzo ^{[1
]}

Carugo, Dario ^{[1
]}

Cheng, Wei ^{[1
]}

Hill, Martyn

Zhang, Xunli ^{[1
]}

机构：

[1] Univ Southampton, Sch Engn Sci, Bioengn Grp, Southampton SO17 1BJ, Hants, England

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2011年 / 357卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

Polymeric micelles; Microfluidic reactors; Nanoprecipitation; Pluronic; CFD; MICROFLUIDIC SYNTHESIS; BLOCK-COPOLYMERS; DRUG; NANOPARTICLES; PLATFORM; SYSTEM;

D O I：

10.1016/j.jcis.2011.01.085

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report the development of a microfluidic-based process for the production of polymeric micelles (PMs) in continuous-flow microreactors where Pluronie (R) tri-block copolymer is used as model polymeric biomaterial relating to drug delivery applications. A flow focusing configuration is used enabling a controllable, and fast mixing process to assist the formation of polymeric micelles through nanoprecipitation which is triggered by a solvent exchange process when organic solutions of the polymer mixed with a non-solvent. We experientially investigate the effect of polymer concentration, flow rate ratio and microreactor dimension on the PMs size characteristics. The mixing process within the microfluidic reactors is further analyzed by computational modeling in order to understand the hydrodynamic process and its implication for the polymeric micells formation process. The results obtained show that besides the effect of the flow rate ratio, the chemical environment in which the aggregation takes place plays an important role in determining the dimensional characteristics of the produced polymeric micelles. It is demonstrated that microfluidic reactors provide a useful platform for the continuous-flow production of polymeric micelles with improved controllability, reproducibility, and homogeneity of the size characteristics. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：243 / 251

页数：9

共 40 条

[11] Laminar mixing in different interdigital micromixers:: II.: Numerical simulations [J].

Hardt, S ;

Schönfeld, F .

AICHE JOURNAL, 2003, 49 (03) :578-584

[12] Experimental and numerical investigation into micro-flow cytometer with 3-D hydrodynamic focusing effect and micro-weir structure [J].

Hou, Hui-Hsiung ;

Tsai, Chien-Hsiung ;

Fu, Lung-Ming ;

Yang, Ruey-Jen .

ELECTROPHORESIS, 2009, 30 (14) :2507-2515

[13] Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles [J].

Jahn, Andreas ;

Stavis, Samuel M. ;

Hong, Jennifer S. ;

Vreeland, Wyatt N. ;

Devoe, Don L. ;

Gaitan, Michael .

ACS NANO, 2010, 4 (04) :2077-2087

[14] A Microfluidic Approach for a Continuous Crystallization of Drug Carrier Nanoparticles [J].

Jasch, Katharina ;

Barth, Nina ;

Fehr, Sonja ;

Bunjes, Heike ;

Augustin, Wolfgang ;

Scholl, Stephan .

CHEMICAL ENGINEERING & TECHNOLOGY, 2009, 32 (11) :1806-1814

[15] Mechanism for rapid self-assembly of block copolymer nanoparticles [J].

Johnson, BK ;

Prud'homme, RK .

PHYSICAL REVIEW LETTERS, 2003, 91 (11)

[16] Flash NanoPrecipitation of organic actives and block copolymers using a confined impinging jets mixer [J].

Johnson, BK ;

Prud'homme, RK .

AUSTRALIAN JOURNAL OF CHEMISTRY, 2003, 56 (10) :1021-1024

[17] Microfluidic platform for controlled synthesis of polymeric nanoparticles [J].

Karnik, Rohit ;

Gu, Frank ;

Basto, Pamela ;

Cannizzaro, Christopher ;

Dean, Lindsey ;

Kyei-Manu, William ;

Langer, Robert ;

Farokhzad, Omid C. .

NANO LETTERS, 2008, 8 (09) :2906-2912

[18] Microfluidic synthesis of colloidal silica [J].

Khan, SA ;

Günther, A ;

Schmidt, MA ;

Jensen, KF .

LANGMUIR, 2004, 20 (20) :8604-8611

[19]

Krishnadasan S, 2007, LAB CHIP, V7, P1434, DOI 10.1039/b711412e

[20] Polymeric micelles for delivery of poorly water-soluble compounds [J].

Kwon, GS .

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2003, 20 (05) :357-403

← 1 2 3 4 →