Preparation of cellulose aerogels from ionic liquid solutions for supercritical impregnation of phytol

被引：29

作者：

Maria Lopes, Joana ^{[1
]}

Najwa Mustapa, Ana ^{[1
,2
]}

Pantic, Milica ^{[3
]}

Dolores Bermejo, Maria ^{[1
]}

Martin, Angel ^{[1
]}

Novak, Zoran ^{[3
]}

Knez, Zeljko ^{[3
]}

Jose Cocero, Maria ^{[1
]}

机构：

[1] Univ Valladolid, Dept Chem Engn & Environm Technol, High Pressure Proc Grp, Calle Doctor Mergelina S-N, E-47011 Valladolid, Spain

[2] Univ Teknologi MARA UiTM, Fac Chem Engn, Shah Alam 40450, Selangor, Malaysia

[3] Univ Maribor, Fac Chem & Chem Engn, Smetanova 17, Maribor 2000, Slovenia

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2017年 / 130卷

关键词：

Supercritical; Impregnation; Phytol; Aerogel; Cellulose; Ionic liquids; CARBON-DIOXIDE; DISSOLUTION; AEROCELLULOSE; FABRICATION; EXTRACTION; SILICA; WOOD; CO2;

D O I：

10.1016/j.supflu.2017.07.018

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m(2) g(-1), pore volume from 0.3 to 2.4 cm(3) g(-1) and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 degrees C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim] [DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry.

引用

页码：17 / 22

页数：6

共 37 条

[1] The preparation of lignocellulosic aerogels from ionic liquid solutions [J].