DNA adducts of ortho-toluidine in human bladder

被引：17
作者：
Boehm, Francine [1 ]
Schmid, Dagmar [2 ]
Denzinger, Stefan [3 ]
Wieland, Wolf F. [3 ]
Richter, Elmar [1 ]
机构：
[1] Univ Munich, Walther Straub Inst, Dept Toxicol, D-80336 Munich, Germany
[2] Univ Munich, Inst Forens Med, D-80336 Munich, Germany
[3] Univ Regensburg, Dept Urol, Caritas St Josef Med Ctr, Regensburg, Germany
来源：
BIOMARKERS | 2011年 / 16卷 / 02期
关键词：
4-aminobiphenyl; carcinogenicity; gas chromatography; mass spectrometry; smoking; TOBACCO-SPECIFIC NITROSAMINES; CARCINOGENIC AROMATIC-AMINES; METHYLATED ANILINES PRESENT; HEMOGLOBIN ADDUCTS; 4-AMINOBIPHENYL-DNA ADDUCTS; MASS-SPECTROMETRY; CIGARETTE-SMOKE; URINARY-BLADDER; O-ANISIDINE; CANCER;
D O I：
10.3109/1354750X.2010.534556
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Methods: Determination of 4-ABP and o-toluidine-releasing DNA adducts in epithelial and submucosal bladder tissues of sudden death victims (SDV: n == 46), and bladder tumours (n == 12) by gas chromatography/mass spectrometry. Results: Above background, 4 and 11 of 12 tumour samples contained adducts of 4-ABP (0.057 +/-+/- 0.125 fmol/mu A mu g DNA) and o-toluidine (8.72 +/-+/- 4.49 fmol/mu A mu g DNA), respectively. Lower adduct levels were present in both epithelial and submucosal bladder tissues of SDV (4-ABP: 0.011 +/-+/- 0.022 and 0.019 +/-+/- 0.047 fmol/mu A mu g DNA; o-toluidine: 0.24 +/-+/- 0.63 and 0.27 +/-+/- 0.70 fmol/mu A mu g DNA). Conclusion: Detection of o-toluidine-releasing DNA adducts support the carcinogenicity of o-toluidine in the human bladder.
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收藏
页码：120 / 128
页数：9
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