Neuroendocrine differentiation prostate cancer: From lab to bedside

被引：41
作者：
Cindolo, Luca
Cantile, Monica
Vacherot, Francis
Terry, Stephane
de la Taille, Alexandre
机构：
[1] G Rummo Hosp, Urol Unit, I-82100 Benevento, Italy
[2] Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, Naples, Italy
[3] INSERM, Fac Med, E 0337, F-75654 Paris 13, France
[4] Univ Paris 12, Fac Med, Paris, France
[5] Grp Hosp Henri Mondor, Serv Urol, APHP, Creteil, France
来源：
UROLOGIA INTERNATIONALIS | 2007年 / 79卷 / 04期
关键词：
prostate cancer; neuroendocrine differentiation; chromogranin A; NeuroD1; LNCaP;
D O I：
10.1159/000109711
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: To discuss the current knowledge on induction, production, sustenance and promotion of neuroendocrine differentiation in human prostate cancer. Methods: Review literature using PubMed search and scientific journal Results: Morphological evidence explains some functional relationship between neuroendocrine and surrounding cells. Transdifferentiation phenomenon and new biochemical pathways could be included in the development of androgen independence and prostate progression. Conclusion: Multiple evidence seems to that a synergistic functional network between epithelial PSA secretory cells and neuroendocrine intraprostatic system is the main trigger for the induction and sustenance of neuroendocrine differentiation. The development of new antineoplastic molecules should consider the multiple of the intercellular network. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码：287 / 296
页数：10
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