Acupuncture therapy for Alzheimer's disease: The effectiveness and potential mechanisms(sic)(sic)(sic)

被引:12
作者
Yin, Wei [1 ]
Lv, Guoying [2 ]
Li, Chuangang [2 ]
Sun, Jinhao [1 ]
机构
[1] Shandong Univ, Sch Basic Med Sci, Dept Anat, Jinan, Peoples R China
[2] Shandong Univ, Dept Anesthesiol, Hosp 2, Jinan, Peoples R China
来源
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2021年 / 304卷 / 11期
关键词
acupuncture; acupuncture point; Alzheimer's disease; mechanisms; traditional Chinese medicine;
D O I
10.1002/ar.24780
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Alzheimer's disease (AD) is a common neurodegenerative disease that accounts for approximately 70% of dementia. Following the global escalation of the aging process, the morbidity of AD is increasing rapidly. The current treatment for AD is mainly limited to medications, such as acetylcholinesterase inhibitors. However, the efficacy of acetylcholinesterase inhibitors in improving memory and cognitive functions is not satisfactory. It is a challenge to find an effective alternative therapy for ameliorating AD symptoms. As an important therapeutic technique in traditional Chinese medicine, acupuncture has been proved effective in treating many neurologic diseases including AD. The efficacy of acupuncture is also acknowledged by the National Institutes of Health of the United States. Here, we summarized the effectiveness of acupuncture for treating AD. Especially, the role of acupuncture at certain acupuncture points in modulating the brain function through meridians activity based on Chinese meridian theory is discussed. How acupuncture at a certain acupoint can improve AD symptoms is also described. Furthermore, the possible molecular mechanisms of acupuncture for AD are reviewed, and the role of acupuncture in modulating signaling molecules in neural protection and homeostasis is highlighted. This study may help to understand the theoretical basis and potential molecular mechanisms of acupuncture therapy for AD.
引用
收藏
页码:2397 / 2411
页数:15
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