Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells

被引：66

作者：

Bernini, Roberta ^{[1
]}

Crisante, Fernanda ^{[1
]}

Merendino, Nicolo ^{[2
]}

Molinari, Romina ^{[2
]}

Soldatelli, Maria Chiara ^{[1
]}

Velotti, Francesca ^{[2
]}

机构：

[1] Univ Tuscia, Dipartimento Agrobiol & Agrochim, I-01100 Viterbo, Italy

[2] Univ Tuscia, Dipartimento Ecol & Sviluppo Econ Sostenibile, I-01100 Viterbo, Italy

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 01期

关键词：

Hydroxytyrosol; alpha-Lipoic acid; Antiproliferative activity; Human colon cancer HT-29 cell line; 2-Iodoxybenzoic acid (IBX); VIRGIN OLIVE OIL; LOW-DENSITY-LIPOPROTEIN; CONVENIENT SYNTHESIS; PHENOLIC-COMPOUNDS; ANTIOXIDANT; OXIDATION; PROLIFERATION; DERIVATIVES; INHIBITION; CHEMISTRY;

D O I：

10.1016/j.ejmech.2010.10.028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel ester of hydroxytyrosol and alpha-lipoic acid was synthesized in satisfactory yield by original and simple procedures and evaluated about its antiproliferative activity on the human colorectal adenocarcinoma HT-29 cell line. The compound exhibited a cell growth inhibitory activity significantly more potent than the corresponding parent natural compounds, very likely due to the induction of cell cycle arrest in the G2/M phase. These data suggest that the novel ester might exert a more effective antitumour activity than hydroxytyrosol and alpha-lipoic acid. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：439 / 446

页数：8

共 60 条

[1] Toward a high yield recovery of antioxidants and purified hydroxytyrosol from olive mill wastewaters [J].