Sintering, crystallisation and biodegradation behaviour of Bioglass®-derived glass-ceramics

被引:252
作者
Boccaccini, Aldo R.
Chen, Qizhi
Lefebvre, Leila
Gremillard, Laurent
Chevalier, Jerome
机构
[1] Imperial Coll London, Dept Mat, London SW7 2BP, England
[2] Inst Natl Sci Appl, CNRS 551020, Dept Mat, F-69621 Villeurbanne, France
关键词
D O I
10.1039/b616539g
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Sintering and crystallisation phenomena in powders of a typical bioactive glass composition (45S5 Bioglass (R)) have been investigated in order to gain further understanding of the processes involved in the fabrication of Bioglass (R) based glass-ceramic scaffolds for tissue engineering applications. In situ experiments in an environmental scanning electron microscope with a heating stage were carried out to follow the morphology of Bioglass (R) particles during sintering and crystallisation. Optimal processing parameters for the manufacture of Bioglass (R) based glass-ceramic scaffolds by the foam-replica technique were determined. To assess the in vitro performance and bioreactivity of Bioglass (R)-derived glass-ceramic scaffolds, the biodegradation of samples in simulated body fluid (SBF) was investigated using various techniques, including SEM, TEM, XRD and EDX. The mechanism of interaction of the glass-ceramic surface with SBF was determined, which involves (i) preferential dissolution at glass/crystal interfaces, (ii) break-down of crystalline particles into very fine grains through preferential dissolution at crystal structural defects, and (iii) amorphisation of the crystalline structure by introduction of point defects produced during ion exchange. The present report thus offers for the first time a complete assessment of the processing parameters, microstructure, and in vitro performance of Bioglassg derived glass-ceramic scaffolds intended for bone tissue engineering.
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页码:27 / 44
页数:18
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