Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action

被引：32

作者：

Garcia, Jose ^{[1
]}

Barluenga, Sofia ^{[1
]}

Beebe, Kristin ^{[2
]}

Neckers, Len ^{[2
]}

Winssinger, Nicolas ^{[1
]}

机构：

[1] Univ Strasbourg, ISIS, UMR 7006, CNRS, F-67000 Strasbourg, France

[2] NCI, Urol Oncol Branch, Bethesda, MD 20892 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 32期

关键词：

deguelin; Hsp90; natural products; tephrosin; total synthesis; CANCER CHEMOPREVENTIVE ACTIVITY; SMALL-MOLECULE INHIBITORS; TARGETING HSP90; ROTENOIDS; NOVOBIOCIN; EFFICIENT; DISEASE; HEAT-SHOCK-PROTEIN-90; OXIDOREDUCTASE; GELDANAMYCIN;

D O I：

10.1002/chem.201001080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) The concise nature and modularity of the synthesis described for deguelin and tephrosin (retrosynthetic analysis depicted) should facilitate access to labeled analogues to dissect the mechanism of action of this important pharmacophore. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9767 / 9771

页数：5

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