In Silico Docking Studies and Evaluation of Antioxidant Activity of Trolox Derivatives: An Analog of Vitamin E

被引：0

作者：

Rawat, Pinki ^{[1
]}

Verma, Saurabh Manaswita ^{[1
]}

Rawat, Preeti ^{[2
]}

Kumar, Piyush ^{[3
]}

机构：

[1] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

[2] CSIR, Dept Photochem, Natl Bot Res Inst, Lucknow 226001, Uttar Pradesh, India

[3] Integral Univ, Dept Pharm, Lucknow 226001, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 01期

关键词：

Antioxidant activity; Docking studies; 2-diphenyl-1-picrylhydrazyl; Hydrogen peroxide; Trolox derivatives; Vitamin E; BREAST-CANCER; DESIGN; STRESS; ACIDS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Because of the significance of the antioxidant role of the natural compound vitamin E and its water-soluble analogue Trolox, 17 Trolox derivatives were designed and performed their antioxidant activity via DPPH free radical scavenging and Hydrogen peroxide scavenging assays. The docking studies were carried out and the results revealed that all compounds displayed better docking score than Trolox. The compounds having hydroxyl substituent at benzopyran ring showed the more potent antioxidant property. The compounds having a bromo group at isatin ring showed less potency. However, eleven compounds (6a, 6b, 6c, 6e, 6f, 6g, 6h, 6j, 6k, 6l, and 6m) were found to reduce DPPH more than the standard drug, Trolox (74% inhibition), which suggests such compounds warrant further study.

引用

页码：63 / 70

页数：8

共 28 条

[1]

Al-Ghorbani MMA, 2018, INDIAN J HETEROCY CH, V28, P379

[2] Vitamin E-analog Trolox prevents endoplasmic reticulum stress in frozen-thawed ovarian tissue of capuchin monkey (Sapajus apella) [J].

Brito, D. C. ;

Brito, A. B. ;

Scalercio, S. R. R. A. ;

Percario, S. ;

Miranda, M. S. ;

Rocha, R. M. ;

Diniz, J. A. P. ;

Oskam, I. C. ;

Van den Hurk, R. ;

Paris, M. C. J. ;

Domingues, S. F. S. ;

Santos, R. R. .

CELL AND TISSUE RESEARCH, 2014, 355 (02) :471-480

[3] Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox [J].

Cordova, Fabiano M. ;

Aguiar, Aderbal S., Jr. ;

Peres, Tanara V. ;

Lopes, Mark W. ;

Goncalves, Filipe M. ;

Pedro, Daniela Z. ;

Lopes, Samantha C. ;

Pilati, Celso ;

Prediger, Rui D. S. ;

Farina, Marcelo ;

Erikson, Keith M. ;

Aschner, Michael ;

Leal, Rodrigo B. .

ARCHIVES OF TOXICOLOGY, 2013, 87 (07) :1231-1244

[4] Novel Trolox derivatives as antioxidants: A DFT investigation [J].

Farmanzadeh, Dvood ;

Najafi, Meysam .

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2016, 81 (03) :277-290

[5] Antioxidants and antioxidant methods: an updated overview [J].

Gulcin, Ilhami .

ARCHIVES OF TOXICOLOGY, 2020, 94 (03) :651-715

[6]

Hamad Ismail, 2010, J Nat Sci Biol Med, V1, P16, DOI 10.4103/0976-9668.71667

[7] Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes [J].

Jin, Ling ;

Tu, Jian ;

Jia, Jianwei ;

An, Wenbin ;

Tan, Huanran ;

Cui, Qinghua ;

Li, Zhixin .

JOURNAL OF TRANSLATIONAL MEDICINE, 2014, 12

[8] Antioxidant properties of conjugates of triterpenic acids with amido derivatives of Trolox [J].

Khairullina, V. R. ;

Gerchikov, A. Ya. ;

Safarova, A. B. ;

Khalitova, R. R. ;

Spivak, A. Yu. ;

Shakurova, E. R. ;

Odinokov, V. N. .

KINETICS AND CATALYSIS, 2011, 52 (02) :186-191

[9]

Kumar P, 2020, INDIAN J HETEROCY CH, V30, P297

[10]

Kumar P, 2020, INDIAN J HETEROCY CH, V30, P395

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