First highly regio- and diastereoselective synthesis of Δ2-pyrazolines by [3+2] cycloaddition of chiral non-racemic Fischer carbene complexes with nitrilimines

被引：25

作者：

Barluenga, J ^{[1
]}

Fernández-Marí, F ^{[1
]}

Aguilar, E ^{[1
]}

Viado, AL ^{[1
]}

Olano, B ^{[1
]}

机构：

[1] Univ Oviedo, CSIC, Unidad Asociada, Inst Quim Organomet Enrique Moles, E-33071 Oviedo, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

关键词：

cycloadditions; carbenes; nitrilimines; pyrazolines;

D O I：

10.1016/S0040-4039(98)00886-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[3+2] Cycloaddition of Fischer carbene complexes with nitrilimines is described for the first time. The "one-pot" conversion of Fischer carbenes into enantiomerically pure Delta(2)-pyrazolines with high regio-and diastereoselectivity is presented as an expeditious route to these compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4887 / 4890

页数：4

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